{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:29:48Z","timestamp":1775791788335,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Clinical and Translational Science grant support","award":["UL1 TR000135"],"award-info":[{"award-number":["UL1 TR000135"]}]},{"name":"Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital diaphragmatic hernia (<jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content>) is a rare anomaly with high mortality and long\u2010term comorbid conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Our aim was to describe the presenting characteristics, treatment, and outcomes of consecutive patients with <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> treated at our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study and identified consecutive neonates treated for <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> from 2001 to 2015 at our institution. For all patients identified, we reviewed hospital and postdischarge data for neonatal, disease, and treatment characteristics. We determined hospital survival overall and also according to the presence of prenatal diagnosis, liver herniation into the chest (<jats:italic>liver up<\/jats:italic>), and the use of extracorporeal membrane oxygenation (<jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content>) in addition to surgery. We evaluated postdischarge chronic conditions in patients with at least one year of follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010eight neonates were admitted for treatment during the study period. In three who were in extremis, life support was withdrawn. The other 35 underwent surgical repair, of whom eight received <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content>. The overall survival was 79% (30\/38). Survival for those who had surgical correction of <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> but did not need <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> was 89% (24\/27); it was 75% (6\/8) for those who received <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> and had surgery. Hospital survival was lower for liver\u2010up vs liver\u2010down <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> (61% [11\/18] vs 95% [19\/20]; odds ratio, 0.08; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 0.01\u20130.77; <jats:italic>P<\/jats:italic> = 0.01). Among survivors, the median duration of hospitalization was 31 (interquartile range, 20\u201373) days. Major chronic pulmonary and gastrointestinal disorders, failure to thrive, and neurodevelopmental delays were the most noted comorbid conditions after discharge, and all were more prevalent in those who required <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The overall survival of neonates with <jats:styled-content style=\"fixed-case\">CDH<\/jats:styled-content> was 79%. Intrathoracic liver herniation was associated with more frequent use of <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content> and greater mortality. A substantial number of survivors, especially those who required <jats:styled-content style=\"fixed-case\">ECMO<\/jats:styled-content>, experienced chronic conditions after discharge.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13046","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T09:26:40Z","timestamp":1487323600000},"page":"314-321","source":"Crossref","is-referenced-by-count":21,"title":["Congenital diaphragmatic hernia: outcomes of neonates treated at Mayo Clinic with and without extracorporeal membrane oxygenation"],"prefix":"10.1111","volume":"27","author":[{"given":"Katarina","family":"Bojani\u0107","sequence":"first","affiliation":[{"name":"Division of Neonatology Department of Obstetrics and Gynecology University Hospital Merkur Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M.","family":"Woodbury","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre N.","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru\u017ea","family":"Grizelj","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Zagreb School of Medicine University Hospital Centre Zagreb Zagreb Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Garth F.","family":"Asay","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher E.","family":"Colby","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Carey","sequence":"additional","affiliation":[{"name":"Department of Pediatric and Adolescent Medicine Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J.","family":"Schears","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toby N.","family":"Weingarten","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darrell R.","family":"Schroeder","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics Mayo Clinic Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juraj","family":"Sprung","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Mayo Clinic Rochester MN 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