{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T23:06:18Z","timestamp":1765667178184,"version":"3.37.3"},"reference-count":5,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T00:00:00Z","timestamp":1490054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Tranexamic acid is an anti\u2010fibrinolytic agent frequently used in pediatric surgery. Common side effects include nausea, flushing, and headache, but in rare instances, it may produce anaphylaxis; with only one previously reported case in a 72\u2010year\u2010old man. We report a case of a delayed anaphylactic reaction in a pediatric patient undergoing posterior spine fusion; and discuss the intraoperative management of the acute event, immunologic confirmation, and subsequent anesthetic approach.<\/jats:p>","DOI":"10.1111\/pan.13141","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T08:57:28Z","timestamp":1490086648000},"page":"774-775","source":"Crossref","is-referenced-by-count":24,"title":["Anaphylactic reaction to tranexamic acid in an adolescent undergoing posterior spinal fusion"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4363-9157","authenticated-orcid":false,"given":"Jennifer","family":"Chiem","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iskra","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Immunology Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Walter","family":"Krengel","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalia","family":"Jimenez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seattle Children's Hospital University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,21]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"The Children's Hospital of Philadelphia. (2015 March) Available at:http:\/\/www.chop.edu\/health-resources\/pedi-crisis-mobile-app-healthcare-providers. Accessed 15 September 2015."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2004.04.012"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.09.022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096-010-9415-8"},{"key":"e_1_2_6_6_1","first-page":"1111","article-title":"Anaphylaxis: Recognition and Treatment","volume":"84","author":"Arnold JJ","year":"2011","journal-title":"Am Fam Physician"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.13141","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13141","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:40:44Z","timestamp":1696225244000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.13141"}},"subtitle":[],"editor":[{"given":"David","family":"Polaner","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,3,21]]},"references-count":5,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1111\/pan.13141"],"URL":"https:\/\/doi.org\/10.1111\/pan.13141","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"type":"print","value":"1155-5645"},{"type":"electronic","value":"1460-9592"}],"subject":[],"published":{"date-parts":[[2017,3,21]]}}}