{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T12:19:32Z","timestamp":1765369172610,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:00:00Z","timestamp":1494806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with congenital heart defects are frequently hospitalized before surgery. This exposes them to a high risk for pathogen colonization. There are limited data on colonization prevalence in the pediatric cardiac population, and limited data concerning its potential role in the risk of developing infections after cardiac surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to verify the impact of preoperative colonization on postoperative infections in a population of pediatric cardiac surgery patients coming from Italy and developing countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study conducted in all the patients aged \u226418 years who underwent pediatric open\u2010heart surgery in the year 2015. Clinical data were retrieved from the institutional database for cardiac surgery patients. Data on swab cultures were retrieved from the laboratory database. Swab colonization was tested for association with infection and other outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 169 children who performed the screening for pathogen colonization, 50% had at least one positive swab. Italian patients were (<jats:italic>P<\/jats:italic>=.001) less likely to be colonized with respect to foreign patients (relative risk 0.17, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.09\u20100.35). Postoperative infections in colonized patients occurred at a similar rate as in noncolonized patients (relative risk 1.24, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.64\u20102.39; <jats:italic>P<\/jats:italic>=.532). Colonized patients had a preoperative stay (<jats:italic>P<\/jats:italic>=.021) longer than noncolonized patients (mean difference 2 days, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.3\u20103.8 days).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results of our study suggest that the impact of preoperative colonization on outcome and postoperative infections may be negligible; larger series are required to clearly define this issue.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13169","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T10:56:50Z","timestamp":1494845810000},"page":"849-855","source":"Crossref","is-referenced-by-count":7,"title":["Preoperative colonization in pediatric cardiac surgery and its impact on postoperative infections"],"prefix":"10.1111","volume":"27","author":[{"given":"Simona","family":"Silvetti","sequence":"first","affiliation":[{"name":"Department of CardioVascular Anesthesia and Intensive Care IRCCS Policlinico San Donato Piazza Edmondo Malan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4915-3572","authenticated-orcid":false,"given":"Marco","family":"Ranucci","sequence":"additional","affiliation":[{"name":"Department of CardioVascular Anesthesia and Intensive Care IRCCS Policlinico San Donato Piazza Edmondo Malan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Isgr\u00f2","sequence":"additional","affiliation":[{"name":"Department of CardioVascular Anesthesia and Intensive Care IRCCS Policlinico San Donato Piazza Edmondo Malan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Villa","sequence":"additional","affiliation":[{"name":"Hospital Health Direction IRCCS Policlinico San Donato Piazza Edmondo Malan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Costa","sequence":"additional","affiliation":[{"name":"Chemistry Laboratory IRCCS Policlinico San Donato Piazza Edmondo Malan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.oa.14-00157"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(96)70052-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2016.59937"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2010.10.030"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1499-z"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2008.08.010"},{"key":"e_1_2_10_8_1","unstructured":"Infection Control Service Communicable Disease Control Branch Guideline for the Management of Patients with Methicillin\u2010resistant Staphylococcus aureus (MRSA) [Approved SA Health Safety & Quality Strategic Governance Committee on: 10 December 2013 Next review due: December 2016].http:\/\/www.sahealth.sa.gov.au\/wps\/wcm\/connect\/bd32928042372b299e5bfeef0dac2aff\/Clinical+Guideline_MRSA_April2014.pdf?MOD=AJPERES. 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