{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T02:35:15Z","timestamp":1772850915525,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to quantify the incidence of anesthesia\u2010related and perioperative mortality at a large tertiary pediatric hospital in South Africa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included all children aged &lt;18\u00a0years who died prior to discharge from hospital and within 30\u00a0days of their last anesthetic at the Red Cross War Memorial Children's Hospital between January 1, 2015 to December 31, 2015. A panel of three senior anesthetists reviewed each death to reach a consensus as to whether: (i) anesthesia caused the death; (ii) anesthesia may have contributed to or influenced the timing of death; or (iii) anesthesia was entirely unrelated to the death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 47 deaths within 30\u00a0days of anesthesia prior to discharge from hospital during this 12\u2010month period. The in\u2010hospital mortality within 24\u00a0h of administration of anesthesia was 16.5 per 10\u00a0000 cases (95% confidence intervals [CI]=7.8\u201025.1) and within 30\u00a0days of administration of anesthesia was 55.3 per 10\u00a0000 cases (95% CI=39.5\u201071.2). Age under 1\u00a0year (OR 4.5; 95% CI=2.5\u20108.0, <jats:italic>P<\/jats:italic>=.012) and cardiac surgery and interventional cardiology procedures (OR 2.5; 95% CI=1.2\u20105.2, <jats:italic>P<\/jats:italic>&lt;.01) were both independent predictors of increased risk of perioperative mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The overall 24\u2010h and 30\u2010day anesthesia\u2010related and in\u2010hospital perioperative mortality rates in our study are comparable with other similar studies from tertiary pediatric centers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13214","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T12:13:48Z","timestamp":1504181628000},"page":"1021-1027","source":"Crossref","is-referenced-by-count":19,"title":["Anesthesia\u2010related and perioperative mortality: An audit of 8493 cases at a tertiary pediatric teaching hospital in South Africa"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-2686","authenticated-orcid":false,"given":"Heidi M.","family":"Meyer","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine Division of Paediatric Anaesthesia Faculty of Health Sciences University of Cape Town Rondebosch South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine Division of Paediatric Anaesthesia Faculty of Health Sciences University of Cape Town Rondebosch South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme S.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine Division of Paediatric Anaesthesia Faculty of Health Sciences University of Cape Town Rondebosch South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"de Kock","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Tygerberg Academic Hospital and Stellenbosch University Parow South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60990-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e328323dac0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2006.01876.x"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000000248"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/50.10.1041"},{"key":"e_1_2_10_7_1","first-page":"412","article-title":"Death due to anaesthesia at Groote Schuur Hospital, Cape Town \u2013 1956\u20131987. Part I incidence","volume":"77","author":"Harrison GG","year":"1990","journal-title":"S Afr Med J"},{"key":"e_1_2_10_8_1","first-page":"176","article-title":"Peri\u2010operative mortality in the anaesthetic service at Tygerberg Hospital","volume":"82","author":"Coetzee A","year":"1992","journal-title":"S Afr Med J"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318213be52"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev286"},{"key":"e_1_2_10_11_1","unstructured":"Safe Surgery SA.South African Paediatric Surgical Outcomes Study (SAPSOS). [Online].2017.www.sapsos.co.za. Accessed May 2 2017."}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.13214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T23:19:43Z","timestamp":1696202383000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.13214"}},"subtitle":[],"editor":[{"given":"Francis","family":"Veyckemans","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2017,8,31]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/pan.13214"],"URL":"https:\/\/doi.org\/10.1111\/pan.13214","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,31]]}}}