{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:17:08Z","timestamp":1776212228787,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T00:00:00Z","timestamp":1515456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Telethon Fellowship Western Australia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cuffed endotracheal tubes are being increasingly used in infants; however, current evidence in the literature mostly includes infants \u2265 3\u2010kg weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this observational study was to compare the short\u2010term outcomes with the use of Microcuff<jats:sup>\u00ae<\/jats:sup> cuffed vs uncuffed endotracheal tubes in neonates &lt; 3 kg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective cohort study in a single\u2010centre, tertiary children's hospital neonatal intensive care unit. The study included all infants &lt; 3 kg receiving Microcuff<jats:sup>\u00ae<\/jats:sup> cuffed endotracheal tubes over the period January 2015 to January 2016. Controls were all infants 2000\u20102999 g receiving an uncuffed endotracheal tube over the period September 2015 to January 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three patients &lt; 3 kg were intubated with cuffed endotracheal tubes. All were inserted in the operating room. Of 23 patients, 14 (60.9%) patients had the cuff inflated in the operating room and none subsequently in the neonatal intensive care unit. The group receiving cuffed endotracheal tubes was compared with 23 patients with uncuffed endotracheal tubes. There was no difference in weight (median 2620 g vs 2590 g, diff in median = 10, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u2212120, 130) or duration of intubation (median 27 vs 44 hours, diff in median = 17, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22125, 46). However, there was a significant difference in gestational age (median 37 vs 35 weeks, diff in median = \u22121, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22122, 0) and age at intubation (median 6 vs 0 days, diff in median = \u22124, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u221210, \u22121). There were no significant differences in the rates of: change of endotracheal tube to find correct size (0\/23 vs 4\/23, <jats:italic>P<\/jats:italic> = .109, OR = 0.13, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.01, 1.41); median ventilator leak reading (0% [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 0%\u201012%] vs 0% [<jats:styled-content style=\"fixed-case\">IQR<\/jats:styled-content> 0%\u20105.5%], <jats:italic>P<\/jats:italic> = .201, diff in median = 0, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> \u22125.5, 0); unplanned extubations (0\/23 vs 2\/23; atelectasis (4\/23 vs 0\/23; endotracheal tube blockage (0\/23 vs 0\/23; pneumonia (0\/23 vs 0\/23; or postextubation stridor (1\/23 vs 2\/23).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This retrospective study with a small sample size found that Microcuff<jats:sup>\u00ae<\/jats:sup> cuffed endotracheal tubes may be safe in neonates &lt; 3 kg. Well\u2010designed randomized controlled trials are needed to address this issue definitively.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13311","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T11:51:28Z","timestamp":1515585088000},"page":"204-209","source":"Crossref","is-referenced-by-count":40,"title":["Cuffed endotracheal tubes in infants less than 3 kg: A retrospective cohort study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7838-015X","authenticated-orcid":false,"given":"Rebecca E.","family":"Thomas","sequence":"first","affiliation":[{"name":"Neonatal Clinical Care Unit Princess Margaret Hospital for Children and King Edward Memorial Hospital for Women Perth WA Australia"},{"name":"Centre for Neonatal Research and Education School of Paediatrics and Child Health University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shripada C.","family":"Rao","sequence":"additional","affiliation":[{"name":"Neonatal Clinical Care Unit Princess Margaret Hospital for Children and King Edward Memorial Hospital for Women Perth WA Australia"},{"name":"Centre for Neonatal Research and Education School of Paediatrics and Child Health University of Western Australia Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Minutillo","sequence":"additional","affiliation":[{"name":"Neonatal Clinical Care Unit Princess Margaret Hospital for Children and King Edward Memorial Hospital for Women Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Hullett","sequence":"additional","affiliation":[{"name":"Department of Paediatric Anaesthesia Princess Margaret Hospital for Children Perth WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max K.","family":"Bulsara","sequence":"additional","affiliation":[{"name":"Chair in 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