{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:15:30Z","timestamp":1791260130746,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T00:00:00Z","timestamp":1516406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"departmental resources"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The prevalence of persistent postsurgical pain in children is over 20% after major surgeries; however, data are scarce on the prevalence, character, and risk factors among children undergoing common ambulatory surgeries. The primary aim of this study was to evaluate the prevalence of persistent pain following pediatric ambulatory surgery at 1, 3, and 6\u00a0months. Secondary aims were to identify risk factors and characterize the pain and consequences of persistent postsurgical pain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> I\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, ages 1 month to 16 years old, undergoing elective hypospadias repair, herniorraphy, orchiopexy, and orthopedic surgery were enrolled in a prospective, longitudinal, observational study at 3 pediatric centers in Italy. All patients received general plus regional anesthesia. Postoperative pain was evaluated using age appropriate pain scales at 1 and 3\u00a0hours. At 1, 3, and 6\u00a0months, pain scores were obtained and Parent's Postoperative Pain Measures (&lt;8\u00a0yo) and Child Activity Limitations Interview (&gt;8\u00a0yo) surveys were administered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 350 patients completed the study. The prevalence of pain at 1, 3, and 6\u00a0months was 24% (84\/350), 6.0% (21\/350), and 4.0% (14\/350), respectively. Inguinal herniorraphy patients experienced significantly higher pain at all 3\u2010time points; 35.6%, 14.9%, and 9.2%. There was no significant association between mean pain scores &gt;4 in <jats:styled-content style=\"fixed-case\">PACU<\/jats:styled-content> and persistent pain. Pain persisting at 6\u00a0months had neuropathic characteristics and frequently interfered with daily activities and sleep.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data support the presence of persistent pain in pediatric patients after common surgeries. Most patients who developed persistent pain at 6\u00a0months had pain at 1\u00a0month. We recommend questioning at follow\u2010up visit about persistent pain and functional impairment with follow\u2010up until resolution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13321","type":"journal-article","created":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T10:10:47Z","timestamp":1516443047000},"page":"231-236","source":"Crossref","is-referenced-by-count":38,"title":["Persistent pain following common outpatient surgeries in children: A multicenter study in Italy"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7862-4863","authenticated-orcid":false,"given":"Valeria","family":"Mossetti","sequence":"first","affiliation":[{"name":"Department of Anesthesia and Intensive Care Citt\u00e0 Della Salute e della Scienza Regina Margherita Children's Hospital Torino Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Boretsky","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Boston Children's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinella","family":"Astuto","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Vittorio Emanuele University Hospital Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno G.","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Papa Giovanni XXIII Hospital Bergamo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zurakowski","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Boston Children's Hospital Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Lio","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Citt\u00e0 Della Salute e della 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