{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:13:48Z","timestamp":1740140028896,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T00:00:00Z","timestamp":1532304000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Assessment of pulmonary blood flow and cardiac output is critical in the postoperative management of patients with single\u2010ventricle physiology or 2\u2010ventricle physiology with intracardiac shunting. Currently, such hemodynamic data are only obtainable by invasive procedures, such as cardiac catheterization or the use of a pulmonary artery catheter. Ready availability of such information, especially if attainable noninvasively, could be a valuable addition to postoperative management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to assess the correlation between volume of <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> elimination obtained by volumetric capnography and pulmonary blood flow in pediatric patients with single\u2010ventricle physiology after stage 1 palliation as well as in patients with other cardiac lesions associated with intracardiac shunting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study included children with congenital or acquired heart disease who underwent cardiac catheterization as part of clinical care. Cardiac output, pulmonary blood flow, and volume of <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> elimination were simultaneously collected. Spearman's rank correlation coefficients were used to assess correlation between measurements after controlling for minute ventilation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010five patients were enrolled and divided into 3 groups. Group 1 (n\u00a0=\u00a08) included single\u2010ventricle patients after stage 1 palliation. Group 2 (n\u00a0=\u00a010) patients had structural heart disease with 2 ventricles and intracardiac shunting. Group 3 (n\u00a0=\u00a017) had structurally normal hearts. Among Group 1 patients, the correlation coefficients (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>) between volume of <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> elimination and pulmonary blood flow and volume of <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> elimination and cardiac output were 0.60 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [0.01\u20100.79] and 0.29 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.74) 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [\u22120.91 \u2010 0.86], respectively. In patients with 2 ventricles associated with intracardiac shunts (Group 2), the correlation coefficients between volume of <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> elimination and pulmonary blood flow and volume of <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> elimination and cardiac output were 0.86 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [0.53 \u2010 0.97] and 0.73 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001) 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [0.29 \u2010 0.95], respectively. Among Group 3 patients, the correlation coefficient between volume of <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> elimination and pulmonary blood flow was 0.66 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.038) 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [0.29 \u2010 0.87].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Volume of <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> elimination may be a surrogate marker of pulmonary blood flow in single\u2010ventricle patients and patients with biventricular physiology with intracardiac shunting. Also, among patients with normal cardiac anatomy, volume of <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content><jats:sub>2<\/jats:sub> elimination may be a marker of cardiac output.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13423","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T08:37:41Z","timestamp":1532335061000},"page":"618-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Correlation between minute carbon dioxide elimination and pulmonary blood flow in single\u2010ventricle patients after stage 1 palliation and 2\u2010ventricle patients with intracardiac shunts: A pilot study"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7643-5110","authenticated-orcid":false,"given":"Awni","family":"Al\u2010Subu","sequence":"first","affiliation":[{"name":"Division of Pediatric Critical Care Medicine Department of Pediatrics University of Wisconsin School of Medicine and Public Health Madison WI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmund","family":"Jooste","sequence":"additional","affiliation":[{"name":"Division of Pediatric Anesthesiology Department of Anesthesiology Duke University Medical Center Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph P.","family":"Hornik","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine Duke University Medical Center Durham NC USA"},{"name":"Duke Clinical Research Institute Department of Pediatrics Duke University Medical Center Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Fleming","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology Department of Pediatrics Duke University Medical Center Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira M.","family":"Cheifetz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Medicine Duke University Medical Center Durham NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Ofori\u2010Amanfo","sequence":"additional","affiliation":[{"name":"Division of Pediatric Critical Care Department of Pediatrics Kravis Children's Hospital at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,23]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"233","article-title":"Invasive hemodynamic monitoring in critically ill patients","volume":"4","author":"Matthay MA","year":"1983","journal-title":"Clin Chest 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