{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:53:50Z","timestamp":1783551230878,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Guangzhou Health and Family Planning Commission Program","award":["20161A011025"],"award-info":[{"award-number":["20161A011025"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Moderate to deep sedation is required for an auditory brainstem response test when high\u2010intensity stimulation is used. Chloral hydrate is the most commonly used sedative, whereas intranasal dexmedetomidine is increasingly used in pediatric non\u2010painful procedural sedations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to compare the sedation success rate after oral chloral hydrate at 50\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> and intranasal dexmedetomidine at 3\u00a0\u03bcg\u00a0kg<jats:sup>\u22121<\/jats:sup> plus buccal midazolam at 0.1\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> for an auditory brainstem response test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Children who required an auditory brainstem response test were recruited and randomly assigned to receive oral chloral hydrate at 50\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup> and intranasal placebo, or intranasal dexmedetomidine at 3\u00a0\u03bcg\u00a0kg<jats:sup>\u22121<\/jats:sup> with buccal midazolam 0.1\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>. The primary outcome was the rate of successful sedation for auditory brainstem response tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010seven out of 82 (69.5%) were successfully sedated after chloral hydrate, while 70 out of 78 (89.7%) children were successfully sedated with dexmedetomidine plus midazolam combination, with the odd ratio (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) for successful sedation between dexmedetomidine plus midazolam combination and chloral hydrate estimated to be 3.84 (1.61\u20109.16), <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002. Dexmedetomidine plus midazolam was associated with quicker onset with median onset time 15 (IQR 11.0\u201019.8) for dexmedetomidine plus midazolam and 20 (IQR 15.0\u201027.0) for chloral hydrate respectively, with difference between median (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) of 5 [3\u20108], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The behavior observed during drug administration of intranasal dexmedetomidine and buccal midazolam was better that of the children who had oral chloral hydrate. No children required oxygen therapy or medical intervention for hemodynamic disturbances in this study and the incidence of hypotension and bradycardia was similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intranasal dexmedetomidine plus buccal midazolam was associated with higher sedation success with deeper level of sedation, with similar discharge time and adverse event rate when compared to chloral hydrate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13498","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T14:10:39Z","timestamp":1538748639000},"page":"1022-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A randomized controlled trial of oral chloral hydrate vs intranasal dexmedetomidine plus buccal midazolam for auditory brainstem response testing in children"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-8703","authenticated-orcid":false,"given":"Bi L.","family":"Li","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre, Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1803-0657","authenticated-orcid":false,"given":"Vivian M.","family":"Yuen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Hong Kong Children's Hospital and Queen Mary Hospital Hong Kong Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia L.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre, Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre, Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun X.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre, Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology Guangzhou Women and Children's Medical Centre, Guangzhou Medical University Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9178-6373","authenticated-orcid":false,"given":"Xing 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