{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:29:24Z","timestamp":1790231364447,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Osteogenesis imperfecta is the collective term for a heterogeneous group of connective tissue syndromes characterized by bone fragility with multisystem involvement and perioperative implications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Literature review of anesthetic management of patients with osteogenesis imperfecta revealed a paucity of data on the incidence of perioperative challenges. We sought to determine the rates of these challenges in our study cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected in a specialty orthopedic hospital from 2008 to 2015 for 83 osteogenesis imperfecta patients undergoing 205 surgeries: 203 orthopedic surgeries and 2 mid\u2010face reconstructive surgeries. Airway management, intravenous access, surgical blood loss, use of peripheral nerve blockade and\/or neuraxial techniques, presence of perioperative fracture, and peak intraoperative temperature were evaluated and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Difficult airway was encountered in 3\/205 (1.5%) cases and perioperative fracture in 2\/205 (1%) cases. Neuraxial anesthesia was attempted in 64\/205 cases with an 87.5% success rate. All peripheral nerve block attempts (33\/205 cases) were successful. Difficult intravenous catheter placement was noted in 8\/205 (4%) cases. Estimated blood loss &gt;10% of estimated blood volume was considered significant, and occurred in 35\/205 (17%) cases. Significant blood loss occurred more often in severe osteogenesis imperfecta types: 18\/76 (23.7%) in Type <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> and 11\/65 (16.9%) in Type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>, whereas only 4\/47 (8.5%) occurred in mild Type I. In our 205 case cohort, osteogenesis imperfecta Type <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> had 5.6 times the odds [(95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.8\u201017.2) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003] of having an anesthetic complication as compared to osteogenesis imperfecta Type I.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with osteogenesis imperfecta undergo frequent anesthetic exposures, but anesthetic challenges in our series were uncommon. Odds of challenges are greater in severe osteogenesis imperfecta Type <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, with significant blood loss and difficulty placing intravenous catheters more likely encountered in the more severe types.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13504","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T10:23:06Z","timestamp":1538994186000},"page":"1050-1058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Anesthesia in children with osteogenesis imperfecta: Retrospective chart review of 83 patients and 205 anesthetics over 7\u00a0years"],"prefix":"10.1111","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4807-7085","authenticated-orcid":false,"given":"Leelach","family":"Rothschild","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Shriners Hospitals for Children Chicago Illinois"},{"name":"Department of Anesthesiology University of Illinois Hospital and Health Sciences System Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica K.","family":"Goeller","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Nebraska Medical Center Omaha Nebraska"},{"name":"Division of Pediatric Anesthesiology Children's Hospital &amp; Medical Center Omaha Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Voronov","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Shriners Hospitals for Children Chicago Illinois"},{"name":"Department of Anesthesiology University of Illinois Hospital and Health Sciences System Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Barabanova","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Illinois Hospital and Health Sciences System Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Shriners Hospitals for Children Chicago 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