{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:07:36Z","timestamp":1791515256400,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,30]],"date-time":"2018-12-30T00:00:00Z","timestamp":1546128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anesthesia services are frequently provided outside of the traditional operating room environment for children. It is unclear if adverse events which occur in off\u2010site anesthetizing locations result in more severe outcomes compared to events in traditional operating rooms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We used a multi\u2010institutional registry of pediatric patients to compare outcomes of perioperative adverse events between location types.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>De\u2010identified data from 24 pediatric tertiary care hospitals participating in the Wake Up Safe registry during 2010\u20102015 were analyzed. Peri\u2010procedural adverse events occurring in operating rooms or off\u2010site locations were included. The primary outcome was whether the adverse event was severe, defined as requiring escalation of care or resulting in temporary or significant harm. Multivariable logistic regression was used to compare location type (operating room vs. off\u2010site) and the likelihood of a severe outcome among reported events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1594 adverse events, of which 362 were associated with off\u2010site anesthetizing locations. In multivariable logistic regression, off\u2010site location was associated with greater odds of severe adverse event outcome (adjusted odds ratio, 1.31; 95% confidence interval: 1.01, 1.69; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.044). Comparing adverse events in cardiac catheterization suites to events in operating rooms confirmed higher odds of severe outcome in the former group (adjusted odds ratio\u00a0=\u00a01.48; 95% confidence interval: 1.05, 2.08; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.025), while this difference was not found for other off\u2010site locations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multivariable analysis of a large registry revealed a greater likelihood of severe outcome for adverse events occurring in cardiac catheterization suites (but not other out of the OR sites), compared to adverse events occurring in the operating room. Additional prospective studies are needed which better control for patient and environmental characteristics and their effect on severe outcomes after anesthesia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13549","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T13:49:32Z","timestamp":1542462572000},"page":"38-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Severe outcomes of pediatric perioperative adverse events occurring in operating rooms compared to off\u2010site anesthetizing locations in the Wake Up Safe Database"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6073-5477","authenticated-orcid":false,"given":"Joshua C.","family":"Uffman","sequence":"first","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children\u2019s Hospital Columbus Ohio"},{"name":"Department of Anesthesiology &amp; Pain Medicine The Ohio State University College of Medicine Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9180-7656","authenticated-orcid":false,"given":"Dmitry","family":"Tumin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children\u2019s Hospital Columbus Ohio"},{"name":"Department of Pediatrics The Ohio State University College of Medicine Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph J.","family":"Beltran","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children\u2019s Hospital Columbus Ohio"},{"name":"Department of Anesthesiology &amp; Pain Medicine The Ohio State University College of Medicine Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Tobias","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children\u2019s Hospital Columbus Ohio"},{"name":"Department of Anesthesiology &amp; Pain Medicine The Ohio State University College of Medicine Columbus Ohio"},{"name":"Department of Pediatrics The Ohio State University College of Medicine Columbus Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.aco.0000236145.38722.2f"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0b013e32835562d8"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2017.01.025"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003398"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12862"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001059"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.03066.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003353"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000266"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002279"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001744"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000268712.00756.dd"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c9f927"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13319"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.11.093"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.anes.0000291440.08068.21"},{"key":"e_1_2_9_18_1","first-page":"931","article-title":"Comparative study of prospective surveillance and voluntary reporting in determining the incidence of adverse drug reactions","volume":"34","author":"Bennett BS","year":"1977","journal-title":"Am J Hosp Pharm"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470200059035"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0565"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/qshc.2009.032979"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1553-7250(14)40043-6"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/PTS.0000000000000469"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.13549","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13549","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T03:48:10Z","timestamp":1694663290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.13549"}},"subtitle":[],"editor":[{"given":"Joseph","family":"Cravero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,30]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/pan.13549"],"URL":"https:\/\/doi.org\/10.1111\/pan.13549","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,30]]},"assertion":[{"value":"2018-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}