{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:35:17Z","timestamp":1789583717092,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Perioperative anxiety is common in pediatric patients undergoing surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to determine whether an infusion of dexmedetomidine prior to hernia repair in children provides better postoperative anxiety outcomes that a preoperative infusion of midazolam.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety 6\u201011\u2010year\u2010old children, who were scheduled to undergo elective hernia repair, were enrolled for this double\u2010blind, randomized controlled trial. Group D (n\u00a0=\u00a045) received an intravenous infusion of dexmedetomidine (0.5\u00a0\u03bcg\/kg) and Group M (n\u00a0=\u00a045) received an intravenous infusion of midazolam (0.08\u00a0mg\/kg) in 20\u00a0mL of normal saline for 10\u00a0minutes before the induction of anesthesia. Pre\u2010 and postoperative scores on the modified Yale Preoperative Anxiety Scale were the main outcomes. Secondary outcomes included systolic blood pressure, diastolic blood pressure, heart rate, and postoperative pain measured on a visual analogue scale and patient satisfaction using a numerical rating scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postoperative anxiety in Group D was significantly lower than preoperative anxiety (2\u00a0hours postoperatively mean difference [95% CI]: 2.83 [0.87\u20104.79], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.036, 4\u00a0hours postoperatively mean difference [95% CI]: 3.29 [1.39\u20105.20], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.005). Preoperative and postoperative anxiety in Group M was similar. Anxiety scores in Group D were also significantly lower than anxiety in Group M 2\u00a0hours (mean difference [95% CI]: 1.89 [0.52\u20103.26], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and 4\u00a0hours (mean difference [95% CI]: 3.32 [1.98\u20104.66], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) postoperatively. Systolic blood pressure, diastolic blood pressure and heart rate were lower in Group D than in Group M after administration of sedative drugs until children left PACU (SBP mean difference [95% CI]: 13.87 [10.30\u201017.43], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, DBP mean difference [95% CI]: 5.96[3.80\u20108.11], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001, HR mean difference [95% CI]: 10.36 [7.58\u201013.13], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Pain was also significantly lower in Group D than in Group M at 2\u00a0hours (median difference [95% CI]: 1 [0.26\u20101.34], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), 4\u00a0hours (median difference [95% CI]: 1 [0.31\u20101.02], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), and 1\u00a0day (median difference [95% CI]: 0 [0.22\u20100.76], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.003) postoperatively. Patient satisfaction scores were significantly higher in Group D than in Group M 1\u00a0day (median difference [95% CI]: 0 [\u22120.83 to \u22120.24], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.006) and somewhat higher 1\u00a0week (median difference [95% CI]: 0 [\u22120.67 to \u22120.04], <jats:italic>P<\/jats:italic>\u00a0=\u00a00.06) postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Compared with midazolam, a single preoperative intravenous dose of dexmedetomidine appears to provide better postoperative anxiolytic effects for children undergoing same\u2010day surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13667","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T16:23:27Z","timestamp":1558715007000},"page":"843-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The comparison of dexmedetomidine and midazolam premedication on postoperative anxiety in children for hernia repair surgery: A randomized controlled trial"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2688-6538","authenticated-orcid":false,"given":"Zhen","family":"Du","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi\u2010Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hunan Children' Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang\u2010Quan","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hunan Children' Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zong\u2010Bing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hunan Children' Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hunan Children' Hospital Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qu\u2010Lian","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"85","volume-title":"Bornstein MH, Genevro JL, EDS. 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