{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:18:05Z","timestamp":1760015885706,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["1R21GM107840"],"award-info":[{"award-number":["1R21GM107840"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["13GRNT13280002"],"award-info":[{"award-number":["13GRNT13280002"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adaptive responses to congenital heart disease result in altered muscle perfusion and muscle metabolism. Such changes may be detectable using noninvasive spectroscopic monitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this study we aimed to determine if resting muscle oxygen saturation (MOx) is lower in children with acyanotic or cyanotic congenital heart disease than in healthy children and to identify differences in muscle oxygen consumption in children with cyanotic and acyanotic congenital heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using a custom fiber optic spectrometer system, optical measurements were obtained from the calf or forearm of 49 patients (17 with acyanotic congenital heart disease, 18 with cyanotic congenital heart disease, and 14 control). Twenty additional control patients were used to develop the analytic model. Spectra were used to determine MOx at baseline, during arterial occlusion, and during reperfusion. The rate of muscle desaturation during arterial occlusion was also evaluated. Two\u2010sample <jats:italic>t<\/jats:italic>\u2010tests were used to compare each heart disease group with the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with acyanotic and cyanotic congenital heart disease had lower baseline MOx than controls. Baseline MOx was 91.3% (CI 85.9%, 96.7%) for acyanotic patients, 91.1% (CI 86.3%, 95.9%) for cyanotic patients, and 98.9% (CI 96.7%, 101.1%) for controls. Similarly, MOx was lower in the acyanotic and cyanotic groups than the controls after reperfusion (84.6% [CI 74.1%, 95.1%] and 82.1% [CI 74.5%, 89.7%] vs 98.9% [96.5%, 101.3%]). The rate of decline in oxygenation was significantly greater in cyanotic patients versus controls (0.46%\/s (CI 0.30%, 0.62%\/s) vs 0.17%\/s (0.13%, 0.21%\/s)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study demonstrates that muscle oxygenation is abnormal in children with both cyanotic and acyanotic congenital heart disease. This suggests that noninvasive monitoring of muscle oxygenation may provide valuable information in situations where children with congenital heart disease may be at risk of hemodynamic compromise.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13668","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T16:38:00Z","timestamp":1558715880000},"page":"850-857","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Assessment of muscle oxygenation in children with congenital heart disease"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8088-0148","authenticated-orcid":false,"given":"Faith J.","family":"Ross","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorilee S. L.","family":"Arakaki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne A.","family":"Ciesielski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Michael","family":"McMullan","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Richards","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Geiduschek","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1440-9742","authenticated-orcid":false,"given":"Gregory","family":"Latham","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seattle Children\u2019s Hospital, University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth A.","family":"Schenkman","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Seattle Children\u2019s Hospital, University of Washington Seattle Washington"},{"name":"Department of Pediatrics University of Washington Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.75.6.614"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0850105"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2004.05.010"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-013-9710-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01309.2004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.10.024"},{"issue":"7","key":"e_1_2_8_8_1","first-page":"075010","article-title":"Noninvasive optical quantification of absolute blood flow, blood oxygenation, and oxygen consumption rate in exercising skeletal muscle","volume":"17","author":"Gurley K","year":"2012","journal-title":"J Biomed Opt"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000787"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2013.05.003"},{"volume-title":"Multivariate Calibration","year":"1989","author":"Martens H","key":"e_1_2_8_11_1"},{"issue":"369","key":"e_1_2_8_12_1","first-page":"4577","article-title":"The use of near\u2010infrared spectroscopy in understanding skeletal muscle physiology: recent developments","volume":"2011","author":"Ferrari M","year":"1955","journal-title":"Philos Trans A Math Phys Eng Sci"},{"issue":"369","key":"e_1_2_8_13_1","first-page":"4591","article-title":"The use of muscle near\u2010infrared spectroscopy in sport, health and medical sciences: recent developments","volume":"2011","author":"Hamaoka T","year":"1955","journal-title":"Philos Trans A Math Phys Eng Sci"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.21.9.091313"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1366\/000370207781269819"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2014.09.002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2008.10.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","unstructured":"AsplundKM SchenkmanKA CiesielskiWA ArakakiL.Photon path depth in tissue phantoms: A comparison of visible and near\u2010infrared wavelengths. Proc SPIE 8945 Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue VI. 2014;89450D.","DOI":"10.1117\/12.2041291"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.11.062"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.09.020"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304249"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-011-9301-5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen210"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aen136"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.13668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13668","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pan.13668","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T04:17:11Z","timestamp":1692505031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.13668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,19]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/pan.13668"],"URL":"https:\/\/doi.org\/10.1111\/pan.13668","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"type":"print","value":"1155-5645"},{"type":"electronic","value":"1460-9592"}],"subject":[],"published":{"date-parts":[[2019,6,19]]},"assertion":[{"value":"2019-01-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}