{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T06:27:14Z","timestamp":1782973634996,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:00:00Z","timestamp":1559088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Open cranial vault reconstruction is frequently performed for craniosynostosis. These procedures often involve high volume blood loss that requires blood transfusion. Antifibrinolytics have been shown to decrease blood loss during these procedures but the optimal dose that maximizes benefits is not known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The primary aim was to evaluate the differences in calculated blood loss between a high infusion rate (40\u00a0mg\/kg\/h) and a low infusion rate (\u226430\u00a0mg\/kg\/h) of epsilon aminocaproic acid after a 100\u00a0mg\/kg loading dose. Secondary aims were to determine if a high infusion rate of epsilon aminocaproic acid was associated with decreased packed red cell transfusion volume and to determine the factors associated with blood loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of children who underwent open cranial vault reconstruction. Using an electronic medical record, we identified patients that fit the inclusion criteria. Demographic, laboratory, transfusion, and perioperative data were collected and statistical analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three patients were included into the study with twenty\u2010three receiving higher infusion rate (40\u00a0mg\/kg\/h) epsilon aminocaproic acid. There was a 14.3\u00a0mL\/kg (95% CI 6.6\u201023.9) decrease in calculated blood loss in the high\u2010dose cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>An EACA bolus of 100\u00a0mg\/kg followed by an infusion of 40\u00a0mg\/kg was associated with a lower calculated blood loss compared to the group who received 100\u00a0mg\/kg EACA and\u00a0\u2264\u00a030\u00a0mg\/kg infusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13671","type":"journal-article","created":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T12:55:44Z","timestamp":1559134544000},"page":"858-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of different dosage regimes of epsilon aminocaproic acid on blood loss in children undergoing craniosynostosis surgery"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1660-6499","authenticated-orcid":false,"given":"Thanh 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