{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T02:55:04Z","timestamp":1794020104404,"version":"4.8.0"},"reference-count":44,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The perioperative management of esophageal atresia\/tracheo\u2010esophageal fistula by open or thoracoscopic approach can be complicated by metabolic derangements. Little is known, however, about the severity of derangements of vital and metabolic parameters in the perioperative period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study is to describe the perioperative courses of vital and metabolic parameters in 101 consecutive neonates undergoing surgical repair of esophageal atresia type C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In a retrospective cohort study, we extracted all data from the electronic anesthetic and medical charts of patients who underwent esophageal atresia type C repair within 30\u00a0days of life (2007\u20102017). We distinguished three types of surgery: primary open, primary thoracoscopic, and primary thoracoscopic surgery converted to open surgery. Descriptive analysis was applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The charts of 117 patients were reviewed: data of 101 were included. The perioperative anesthetic management was not standardized; various methods and medications were used for anesthesia induction and maintenance. Intraoperative blood gas analysis data of 72 patients were available and showed derangements regardless of type of surgery. The median pH\u2010value decreased to 7.21 [IQR 7.14\u20107.30] and a pH\u2010value below 7.20 was found in 29 patients; in four cases below 7.0, with the lowest value 6.83. The median PaCO<jats:sub>2<\/jats:sub> reached an upper level of 7.5kPa [IQR 5.8\u20109.2]; in 13 cases above 10.0kPa, with a peak value of 25.8kPa. These high PaCO<jats:sub>2<\/jats:sub> levels fluctuated with lowest measured PaCO<jats:sub>2<\/jats:sub> of median 5.6 [IQR 4.5\u20106.6], with the lowest value 2.8kPa. The median PaO<jats:sub>2<\/jats:sub> level reached an upper level of 16.9kPa [IQR 11.8\u201025.7], in 22 cases above 20.0kPa, with a peak value of 50.0kPa. These high levels fluctuated with lowest measured PaO<jats:sub>2<\/jats:sub> levels of median 8.3kPa [IQR 6.73\u201010.5]; the lowest PaO<jats:sub>2<\/jats:sub> value was 4.7\u00a0kPa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Open and thoracoscopic correction of esophageal atresia were associated with periods of severe metabolic derangements. These events need to be taken into account for the evaluation of esophageal atresia (surgical) care and in evaluations of short\u2010 and long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13711","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T13:14:52Z","timestamp":1564060492000},"page":"1024-1032","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Perioperative management of esophageal atresia\/tracheo\u2010esophageal fistula: An analysis of data of 101 consecutive patients"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8222-1848","authenticated-orcid":false,"given":"Camille E.","family":"van Hoorn","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A.","family":"Costerus","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Erasmus MC\u2010Sophia Children's Hospital Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rene M. 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