{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:51:21Z","timestamp":1747187481927,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K20092","17K16728"],"award-info":[{"award-number":["16K20092","17K16728"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It can be difficult to determine the appropriate ventilator settings to maintain normocapnia in children undergoing general anesthesia for surgery for moyamoya disease, especially immediately following anesthesia induction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We conducted this study to attempt to derive an equation to predict the appropriate ventilator settings and subsequently validated the accuracy of the equation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of 91 pediatric patients less than 18\u00a0years of age who underwent cerebral revascularization for moyamoya disease at our institution. Fifty\u2010eight patients were used to derive the equation, and the subsequent 33 patients were used to validate the equation. We calculated the required respiratory rate to attain normocapnia based on the median of all values of the minute volume during normocapnia (estimated partial pressure of arterial carbon dioxide of 38\u201042\u00a0mm\u00a0Hg) and the assumption that the tidal volume was 8\u00a0mL\/kg body weight. We derived the regression equation from the derivation data set where the required respiratory rate to attain normocapnia was represented by age. We simplified the equation by rounding coefficients to the nearest integer. The level of agreement between the respiratory rate predicted from the equation and the actual required respiratory rate was assessed in the validation group using Bland\u2010Altman analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The derived equation is tidal volume\u00a0=\u00a08\u00a0mL\/kg body weight, respiratory rate\u00a0=\u00a024\u2010age\/min. Bland\u2010Altman analysis in the validation group revealed that the mean bias between the predicted and actual respiratory rate was 0.29 (standard deviation, 3.67). The percentage of cases where the predicted rate was within\u00a0\u00b1\u00a010% and\u00a0\u00b1\u00a020% of the actual rate was 42.4% and 66.7%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We derived and validated a simple and easily applicable equation to predict the ventilator settings required to attain normocapnia during general anesthesia in children with moyamoya disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13764","type":"journal-article","created":{"date-parts":[[2019,11,16]],"date-time":"2019-11-16T12:59:49Z","timestamp":1573909189000},"page":"50-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Derivation and validation of an equation to determine the optimal ventilator setting in children undergoing intracranial revascularization surgery: A single\u2010center retrospective study"],"prefix":"10.1111","volume":"30","author":[{"given":"Jumpei","family":"Kohara","sequence":"first","affiliation":[{"name":"Department of Anesthesia Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Kyoto University Hospital Kyoto Japan"},{"name":"Department of Healthcare Epidemiology School of Public Health in the Graduate School of Medicine Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikashi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Kyoto University Hospital Kyoto Japan"},{"name":"Department of Pharmacoepidemiology Graduate School of Medicine and Public Health Kyoto University Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Shiraki","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Fukagawa","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2770-4262","authenticated-orcid":false,"given":"Toshiyuki","family":"Mizota","sequence":"additional","affiliation":[{"name":"Department of Anesthesia Kyoto University Hospital Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804622"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70240-0"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3171\/2009.1.FOCUS08310"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000470"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198302000-00033"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2005.01576.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03009765"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199606000-00011"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005400050043"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008506-199210000-00003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03011270"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199007000-00017"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-0697"},{"key":"e_1_2_9_15_1","first-page":"716","volume-title":"Pediatric Anesthesia: basic Principles, State of the Art, Future","author":"Wilton N","year":"2011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181aee5dd"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpa.2015.10.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1955.7.4.451"},{"key":"e_1_2_9_19_1","unstructured":"Centers for disease control and prevention. Childhood overweight and obesity.2018. Available at:https:\/\/www.cdc.gov\/obesity\/childhood\/index.html. Accessed 2019\/5\/2."},{"issue":"246","key":"e_1_2_9_20_1","first-page":"1","article-title":"2000 CDC growth charts for the United States: methods and development","author":"Kuczmarski RJ","year":"2002","journal-title":"Vital Health Stat 11"},{"key":"e_1_2_9_21_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1651-2227.2006.tb02378.x","article-title":"WHO child growth standards based on length\/height, weight and age","volume":"450","author":"WHO Multicentre Growth Reference Study Group","year":"2006","journal-title":"Acta Paediatr Suppl"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/978-1-4757-3462-1","volume-title":"Regression Modeling Strategies: with Applications to Linear Models, Logistic and Ordinal Regression, and Survival analysis","author":"Harrell FE","year":"2001"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-196905000-00028"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/10915810290096630"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/62.1.70"},{"key":"e_1_2_9_26_1","first-page":"444","volume-title":"Miller\u2019s Anesthesia","author":"Kavanagh BP","year":"2015"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.13764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pan.13764","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T02:08:15Z","timestamp":1722046095000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.13764"}},"subtitle":[],"editor":[{"given":"Susan","family":"Goobie","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,11,28]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/pan.13764"],"URL":"https:\/\/doi.org\/10.1111\/pan.13764","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"type":"print","value":"1155-5645"},{"type":"electronic","value":"1460-9592"}],"subject":[],"published":{"date-parts":[[2019,11,28]]},"assertion":[{"value":"2019-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}