{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T02:05:47Z","timestamp":1762999547124,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21 HD072845"],"award-info":[{"award-number":["R21 HD072845"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS107417","K08 NS080984","R01 NS060703","R21 NS095036"],"award-info":[{"award-number":["R01 NS107417","K08 NS080984","R01 NS060703","R21 NS095036"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Current pediatric resuscitation guidelines suggest that resuscitators using an advanced airway deliver 8\u201010 breaths per minute while carefully avoiding excessive ventilation. In the intraoperative setting, having a dedicated ventilation rescuer may be difficult because of limited personnel. Continuing pressure\u2010controlled mechanical ventilation during resuscitation for intraoperative cardiac arrest reduces personnel needed and the risk of hyperventilation but might risk hypoventilation during chest compression delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine whether the use of pressure\u2010controlled mechanical ventilation at prearrest settings provides normoxia and normocarbia during resuscitation from cardiac arrest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed combined data from preclinical randomized controlled trials. Two\u2010week\u2010old swine (3\u20104\u00a0kg) underwent asphyxia\u2010induced cardiac arrest. Animals were resuscitated with periods of basic and advanced life support. During resuscitation, pressure\u2010controlled mechanical ventilation was delivered at the prearrest respiratory rate, peak inspiratory pressure, and positive end\u2010expiratory pressure. Arterial blood gases were measured prearrest, at 11\u00a0minutes of asphyxia, and at 8 and 20\u00a0minutes of cardiopulmonary resuscitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Piglets (n\u00a0=\u00a0154) received pressure\u2010controlled mechanical ventilation before and during cardiopulmonary resuscitation with a peak inspiratory pressure of 14\u201015\u00a0cm H<jats:sub>2<\/jats:sub>O, positive end\u2010expiratory pressure of 4\u00a0cm H<jats:sub>2<\/jats:sub>O, 20 breaths\/minute, and an inspiratory:expiratory ratio of 1:2. During asphyxia, the arterial blood gas showed the expected severe hypercarbia and hypoxia. Continuing pressure\u2010controlled mechanical ventilation using prearrest parameters and increasing the FiO<jats:sub>2<\/jats:sub> to 1.0 returned the PaCO<jats:sub>2<\/jats:sub> to prearrest levels and slightly increased the partial pressure of arterial oxygen at 8 and 20\u00a0minutes of cardiopulmonary resuscitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this piglet model of resuscitation from asphyxial arrest, pressure\u2010controlled mechanical ventilation during cardiopulmonary resuscitation at the prearrest ventilator settings with an FiO<jats:sub>2<\/jats:sub> of 1.0 provides adequate oxygenation and restores normocarbia. Clinical investigation is warranted to determine the benefits of continuing pressure\u2010controlled mechanical ventilation at prearrest parameters during pediatric cardiopulmonary resuscitation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13820","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T09:24:48Z","timestamp":1578129888000},"page":"462-468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The use of pressure\u2010controlled mechanical ventilation in a swine model of intraoperative pediatric cardiac arrest"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7453-5011","authenticated-orcid":false,"given":"Francis M.","family":"Lapid","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caitlin E.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sapna R.","family":"Kudchadkar","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Department of Pediatrics Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Department of Physical Medicine &amp; Rehabilitation Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Department of Pediatrics Johns Hopkins University School of Medicine Baltimore MD USA"},{"name":"Division of Health Sciences Informatics Department of Anesthesiology Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond C.","family":"Koehler","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-0746","authenticated-orcid":false,"given":"Donald H.","family":"Shaffner","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.smj.0000182177.01436.70"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.971085"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2010.08.027"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000450"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001299"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001968"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000268712.00756.dd"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3182a1f3eb"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1553-2712.1995.tb03624.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-017-0061-2"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.05964"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000265"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000126594.79136.61"},{"key":"e_1_2_10_15_1","first-page":"862","article-title":"Comparison of a 10\u2010breaths\u2010per\u2010minute versus a 2\u2010breaths\u2010per\u2010minute strategy during cardiopulmonary resuscitation in a porcine model of cardiac arrest","volume":"53","author":"Lurie KG","year":"2008","journal-title":"Respir Care"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2011.07.034"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198207000-00002"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162185"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2011.03.020"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2018.08.031"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2011.06345.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2008.12.014"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13820","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pan.13820","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T14:56:18Z","timestamp":1694012178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.13820"}},"subtitle":[],"editor":[{"given":"Chandra","family":"Ramamoorthy","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1,27]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1111\/pan.13820"],"URL":"https:\/\/doi.org\/10.1111\/pan.13820","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"type":"print","value":"1155-5645"},{"type":"electronic","value":"1460-9592"}],"subject":[],"published":{"date-parts":[[2020,1,27]]},"assertion":[{"value":"2019-05-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}