{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:17:50Z","timestamp":1789402670647,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,24]],"date-time":"2020-02-24T00:00:00Z","timestamp":1582502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The patent ductus arteriosus is a cardiac lesion commonly found in premature neonates. Though surgical closure via thoracotomy is the most definitive treatment option, it is associated with significant morbidity. New catheter\u2010based closure options offer a potentially safer alternative treatment, even in premature neonates. However, no literature reports the anesthetic techniques, challenges, and risks associated with this procedure in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study documents the anesthetic challenges and potential complications associated with the management of catheter\u2010based closure of the ductus arteriosus in neonates under 3\u00a0kg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This single\u2010center, retrospective study examined patients who underwent catheter\u2010based ductus arteriosus closure between August 2015 and February 2019. A clinical protocol for anesthetic management of these patients was utilized throughout the study period. Clinical outcomes considered were new hemodynamic instability or vasoactive medication requirements, hypothermia, prolonged intubation (&gt;3\u00a0days postoperatively), postprocedure acute kidney injury, perioperative red blood cell transfusion, and accidental extubation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010six neonates underwent 78 procedures. No patient developed perioperative hemodynamic instability, vasoactive medication requirements, or acute kidney injury. Four patients (5%) required red blood cell transfusion, two (3%) became hypothermic, and one (1%) was accidentally extubated. Closure was achieved in 73 patients (96%) on the first attempt. However, 17 patients (40%) required prolonged periods of mechanical ventilation following the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite multiple clinical and logistical challenges, anesthetic risk associated with catheter\u2010based PDA closure in small neonates can be effectively managed through standardized and multidisciplinary care.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13838","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T15:58:45Z","timestamp":1581350325000},"page":"506-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Anesthetic management of catheter\u2010based patent ductus arteriosus closure in neonates weighing &lt;3\u00a0kg: A Retrospective Observational Study"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0302-1977","authenticated-orcid":false,"given":"Richard","family":"Hubbard","sequence":"first","affiliation":[{"name":"Department of Anesthesiology University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayla","family":"Edmonds","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rydalch","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Texas Health Science Center at Houston Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Pawelek","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Texas Health Science Center at Houston 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