{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T19:46:42Z","timestamp":1759693602559,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypothermia and its combination with hypocapnia are frequently associated with anesthesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The goal was to investigate the effects of hypothermia and hypothermia combined with hypocapnia (hypothermia\u2010hypocapnia) on cerebral tissue oxygenation in anesthetized piglets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty anesthetized piglets were randomly allocated to hypothermia (n\u00a0=\u00a010) or hypothermia\u2010hypocapnia (n\u00a0=\u00a010). Cerebral monitoring comprised a tissue oxygen partial pressure (PtO<jats:sub>2<\/jats:sub>), a laser Doppler probe, and a near\u2010infrared spectroscopy sensor, measuring regional oxygen saturation (rSO<jats:sub>2<\/jats:sub>). After baseline recordings, hypothermia (35.5\u201036.0\u00b0C) with or without hypocapnia (target PaCO<jats:sub>2<\/jats:sub>: 28\u201030\u00a0mm\u00a0Hg) was induced. Once treatment goals were achieved (Tr0), they were maintained for 30\u00a0minutes (Tr30).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No changes in PtO<jats:sub>2<\/jats:sub> but a significant increase in rSO<jats:sub>2<\/jats:sub> (Tr0 (mean difference 8.9[95% CI for difference3.99 to 13.81], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001); Tr30 (10.8[6.20 to 15.40], <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001)) were detected during hypothermia. With hypothermia\u2010hypocapnia, a decrease in PtO<jats:sub>2<\/jats:sub> (Tr0 (\u22123.2[\u22126.01 to \u22120.39], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.021; Tr30 (\u22123.3[\u22125.8 to \u22120.80], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.006)) and no significant changes in rSO<jats:sub>2<\/jats:sub> occurred. Cerebral blood flow decreased significantly from baseline to Tr0 independently of treatment (\u22120.89[\u22120.18 to \u22120.002], <jats:italic>P<\/jats:italic>\u00a0=\u00a0.042), but this was more consistently observed with hypothermia\u2010hypocapnia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The hypothermia\u2010induced reduction in oxygen delivery was compensated by lowered metabolic demand. However, hypothermia was not able to compensate for an additional reduction in oxygen delivery caused by simultaneous hypocapnia. This resulted in a PtO<jats:sub>2<\/jats:sub> drop, which was not reflected by a downshift in rSO<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13943","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T13:43:40Z","timestamp":1591537420000},"page":"970-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of hypothermia and hypothermia combined with hypocapnia on cerebral tissue oxygenation in piglets"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9346-3308","authenticated-orcid":false,"given":"Simone K.","family":"Ringer","sequence":"first","affiliation":[{"name":"Department of Clinical Diagnostics and Services, Section Anaesthesiology Vetsuisse Faculty University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3590-5171","authenticated-orcid":false,"given":"Nicola G.","family":"Clausen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University Children's Hospital Zurich Zurich Switzerland"},{"name":"Children's Research Centre University Children's Hospital of Zurich University of Zurich Zurich Switzerland"},{"name":"Department of Anaesthesiology and Intensive Care Odense University Hospital Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"Spielmann","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University Children's Hospital Zurich Zurich Switzerland"},{"name":"Children's Research Centre University Children's Hospital of Zurich University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5822-9591","authenticated-orcid":false,"given":"Markus","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology University Children's Hospital Zurich Zurich Switzerland"},{"name":"Children's Research Centre University Children's Hospital of Zurich University of Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12994"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-3025"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00250"},{"key":"e_1_2_9_5_1","first-page":"CD001048","article-title":"Hypothermia for traumatic brain injury","volume":"9","author":"Lewis SR","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04962"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.10.019"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-5153.2006.00177.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.07.041"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13736"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199902000-00011"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael137"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/140213"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.11.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03273-8"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/88.2.188"},{"key":"e_1_2_9_17_1","first-page":"20","article-title":"Increased brain tissue oxygen tension in children with traumatic brain injury using temperature\u2010corrected guided ventilation during prophylactic hypothermia","volume":"14","author":"Schibler A","year":"2012","journal-title":"Crit Care Resusc"},{"key":"e_1_2_9_18_1","first-page":"43","article-title":"Effect of mild hypothermia on partial pressure of oxygen in brain tissue and brain temperature in patients with severe head injury","volume":"5","author":"Zhang S","year":"2002","journal-title":"Chin J Traumatol"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-009-1037-x"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/95.12.775"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S106915"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200102000-00028"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199512000-00017"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-200006000-00005"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200009000-00024"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.05.099"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012457"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169-015-0079-9"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1373.2000.22314.x"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpan.13943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13943","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pan.13943","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.13943","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T20:17:38Z","timestamp":1693945058000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.13943"}},"subtitle":[],"editor":[{"given":"Laszlo","family":"Vutskits","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,25]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/pan.13943"],"URL":"https:\/\/doi.org\/10.1111\/pan.13943","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"type":"print","value":"1155-5645"},{"type":"electronic","value":"1460-9592"}],"subject":[],"published":{"date-parts":[[2020,6,25]]},"assertion":[{"value":"2019-12-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}