{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:29:03Z","timestamp":1773329343676,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["ZYLX 201810"],"award-info":[{"award-number":["ZYLX 201810"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81471902"],"award-info":[{"award-number":["81471902"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011002","name":"National Natural Science Foundation of China-Yunnan Joint Fund","doi-asserted-by":"publisher","award":["81871592"],"award-info":[{"award-number":["81871592"]}],"id":[{"id":"10.13039\/501100011002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Impaired cerebrovascular reactivity to carbon dioxide was proposed to contribute to neurological morbidity in children undergoing cardiac surgery. The objective of this study was to assess carbon dioxide reactivity and regional cerebral oxygen saturation in children younger than 3\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study enrolled children younger than 3\u00a0years undergoing ventricular septal defect repair. The cohort was divided into three age groups: younger than 6\u00a0months, 6\u201012\u00a0months, and 12\u201036\u00a0months. Under steady\u2010state anesthesia, carbon dioxide reactivity was calculated by measuring changes in middle cerebral artery blood flow velocity using transcranial Doppler sonography. Regional cerebral oxygen saturation changes were measured by near\u2010infrared spectroscopy while endtidal carbon dioxide pressure was adjusted from 30 to 45\u00a0mm\u00a0Hg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Carbon dioxide reactivity showed a statistically significant increasing relationship with age (younger than 6\u00a0months group: 4.42%\u00a0\u00b1\u00a02.73%, 6\u201012\u00a0months group: 5.86%\u00a0\u00b1\u00a01.91%, 12\u201036\u00a0months group: 7.58%\u00a0\u00b1\u00a01.49%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Regional cerebral oxygen saturation showed a statistically significant increasing relationship with age (younger than 6\u00a0months group: 65%\u00a0\u00b1\u00a06%, 6\u201012\u00a0months group: 68%\u00a0\u00b1\u00a05%, 12\u201036\u00a0months group: 70%\u00a0\u00b1\u00a05%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.027). Regional cerebral oxygen saturation showed a statistically significant increasing relationship with endtidal carbon dioxide pressure in all children (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Abnormal carbon dioxide reactivity is prevalent in children younger than 3\u00a0years and the degree varies according to age.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.13967","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T11:14:12Z","timestamp":1594379652000},"page":"977-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Age\u2010related cerebrovascular carbon dioxide reactivity in children with ventricular septal defect younger than 3\u00a0years"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6062-0135","authenticated-orcid":false,"given":"Boqun","family":"Cui","sequence":"first","affiliation":[{"name":"Anesthesia Center Capital Medical University Affiliated Beijing Anzhen Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Ou\u2010Yang","sequence":"additional","affiliation":[{"name":"Anesthesia Center Capital Medical University Affiliated Beijing Anzhen Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siyuan","family":"Xie","sequence":"additional","affiliation":[{"name":"Anesthesia Center Capital Medical University Affiliated Beijing Anzhen Hospital Beijing China"},{"name":"Department of Anesthesiology Capital Institute of Pediatrics affiliated Children's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duomao","family":"Lin","sequence":"additional","affiliation":[{"name":"Anesthesia Center Capital Medical University Affiliated Beijing Anzhen Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ma","sequence":"additional","affiliation":[{"name":"Anesthesia Center Capital Medical University Affiliated Beijing Anzhen Hospital Beijing 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