{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:41:26Z","timestamp":1781851286667,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T00:00:00Z","timestamp":1599955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of this study was to report the incidence of perioperative adverse events occurring in infants undergoing diode laser photocoagulation of retinopathy of prematurity and to identify clinical risk factors that may affect the incidence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of anesthetic and medical records of premature infants who were treated in the neonatal intensive care unit or an operating theater with laser photocoagulation in our institution between January 2014 and December 2019. Infants less than 38\u00a0weeks post\u2010menstrual age or less than 2000 grams were considered high risk for complications. Electronic medical records were evaluated for clinical and demographic characteristics, comorbidities, and perioperative complications of anesthesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one infants (39 males, 22 females) underwent 72 laser treatments. The mean gestational age was 25.3\u00a0weeks (SD 1.6), and mean birth weight was 730 grams (SD 202). At treatment, the mean postmenstrual age was 37.5\u00a0weeks (SD 2.7) and weight was 2320\u00a0g (SD 610). Laser therapy was performed in an operating theater in 66 procedures (91.7%) and in the neonatal unit in 6 cases (8.3%). Twenty\u2010nine (40.3%) laser surgeries occurred outside normal week\u2010day daytime operating hours. Intraoperative hypotension occurred in 12 procedures (16.7%) but was not significantly different in high\u2010risk infants (16.1% vs 16.7% OR 0.94 <jats:italic>P<\/jats:italic>\u00a0=\u00a0.94) or in procedures performed in\u2010hours (16.3% vs 17.2% OR 0.93 <jats:italic>P<\/jats:italic>\u00a0=\u00a0.91). Post\u2010extubation apnea occurred in 21 procedures (29%) but was not significantly different in high\u2010risk infants (29.0% vs 27.3% OR 0.98 <jats:italic>P<\/jats:italic>\u00a0=\u00a0.34) or in procedures performed in\u2010hours (27.9% vs 31.1% OR 0.86 <jats:italic>P<\/jats:italic>\u00a0=\u00a0.77). Infants remained intubated at the end of the procedure in 58 (80.5%) cases and 29 (40.3%) remained ventilated more than 24\u00a0hours after the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The incidence of perioperative adverse events was not associated with patient's age, current weight, timing, or location of the procedure. Extubating infants at the end of the procedure is however associated with a high rate of apneas and bradycardia, and consideration should be given to keeping low weight infants undergoing prolonged procedures out\u2010of\u2010hours intubated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14008","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T18:22:16Z","timestamp":1598552536000},"page":"1261-1268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anesthesia management of laser photocoagulation for retinopathy of prematurity. A retrospective review of perioperative adverse events"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3375-0142","authenticated-orcid":false,"given":"Balvindar","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Paediatric Anaesthesia and Pain Management Royal Children's Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Carden","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Royal Children's Hospital Parkville Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Paediatric Anaesthesia and Pain Management Royal Children's Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4225-1185","authenticated-orcid":false,"given":"Geoff","family":"Frawley","sequence":"additional","affiliation":[{"name":"Department of Paediatric Anaesthesia and Pain Management Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Parkville Victoria Australia"},{"name":"Critical Care and Neurosciences Theme Murdoch Children's Research Institute Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2018-3061"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60178-6"},{"key":"e_1_2_10_4_1","first-page":"233","article-title":"Final results of the Early Treatment for Retinopathy of Prematurity (ETROP) randomized 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