{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:46:00Z","timestamp":1792147560032,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Data on cerebral pressure\u2010flow autoregulation in the youngest children are scarce. We studied the correlation between mean arterial pressure and cerebral tissue oxygen saturation (rSO\n                      <jats:sub>2<\/jats:sub>\n                      ) by near\u2010infrared spectroscopy (NIRS) in patients undergoing nose, lip, and palate surgery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>We tested the hypothesis that cerebral pressure\u2010flow autoregulation is impaired in children less than 1\u00a0year undergoing surgery and general anesthesia with sevoflurane under controlled mechanical ventilation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      After approval from the Ethical board, 15 children aged &lt;1\u00a0year were included. Before anesthesia induction, a NIRS sensor (INVOS\n                      <jats:sup>TM<\/jats:sup>\n                      , Medtronic, Minneapolis, USA) was placed over the cerebral frontal lobe. Frontal rSO\n                      <jats:sub>2<\/jats:sub>\n                      , a surrogate for cerebral perfusion, mean arterial pressure, end\u2010tidal CO\n                      <jats:sub>2<\/jats:sub>\n                      \u2010 and sevoflurane concentration, and arterial oxygen saturation were sampled every minute after the induction. A repeated measures correlation analysis was performed to study correlation between mean arterial pressure and cerebral rSO\n                      <jats:sub>2<\/jats:sub>\n                      , and the repeated measures correlation coefficient (r\n                      <jats:sub>rm<\/jats:sub>\n                      ) was calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen patients, aged 7.7\u00a0\u00b1\u00a01.9\u00a0months, were studied. rSO\n                      <jats:sub>2<\/jats:sub>\n                      showed a positive correlation with mean arterial pressure ([95% CI: 9.0\u201012.1],\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) with a moderate to large effect size (r\n                      <jats:sub>rm<\/jats:sub>\n                      \u00a0=\u00a00.462), indicating an impaired cerebral pressure\u2010flow autoregulation. The slopes of the rSO\n                      <jats:sub>2<\/jats:sub>\n                      \u2010mean arterial pressure correlations were steeper in patients who were hypotensive (mean arterial pressure &lt;50\u00a0mm Hg) compared to patients having a mean arterial pressure \u226550\u00a0mm Hg, indicating that at lower mean arterial pressure, the cerebral pressure dependence of cerebral oxygenation is even more pronounced.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>During sevoflurane anesthesia in the youngest pediatric patients, cerebral perfusion is pressure\u2010dependent, suggesting that the efficiency of the cerebral blood flow autoregulation is limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pan.14146","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T01:01:41Z","timestamp":1612400501000},"page":"563-569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Cerebral autoregulation in infants during sevoflurane anesthesia for craniofacial surgery"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7518-8915","authenticated-orcid":false,"given":"Pether","family":"Jildenst\u00e5l","sequence":"first","affiliation":[{"name":"Institute of Health and Care Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Anesthesia and Intensive Care Institute for Clinical Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Anesthesiology, Surgery and Intensive Care Sahlgrenska University Hospital Gothenburg Sweden"},{"name":"Department of Anaesthesiology and Intensive Care \u00d6rebro University Hospital and School of Medical Sciences \u00d6rebro University \u00d6rebro Sweden"},{"name":"Department of Health Sciences Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Widarsson Norbeck","sequence":"additional","affiliation":[{"name":"Institute of Health and Care Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Anesthesiology, Surgery and Intensive Care Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Snygg","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Institute for Clinical Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Anesthesiology, Surgery and Intensive Care Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven\u2010Erik","family":"Ricksten","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Institute for Clinical Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Anesthesiology, Surgery and Intensive Care Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Lannemyr","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care Institute for Clinical Sciences Sahlgrenska Academy University of Gothenburg Gothenburg Sweden"},{"name":"Department of Anesthesiology, Surgery and Intensive Care Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"issue":"2","key":"e_1_2_12_2_1","first-page":"161","article-title":"Cerebral autoregulation","volume":"2","author":"Paulson OB","year":"1990","journal-title":"Cerebrovasc Brain Metab 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