{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T07:02:47Z","timestamp":1778569367825,"version":"3.51.4"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Surgery results in systemic inflammation, which can affect the central nervous system, leading to changes in mood, emotion, and behavior. Our previous study has shown that compared to midazolam, dexmedetomidine premedication effectively decreased children's postoperative anxiety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate whether dexmedetomidine infusion before hernia repair alleviates postoperative systemic inflammation in children and whether postoperative anxiety may be associated with postoperative inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective double\u2010blind randomized controlled trial was conducted in 120 children scheduled to undergo elective hernia repair. Before anesthesia induction, all children received an intravenous infusion consisted of dexmedetomidine (<jats:italic>n<\/jats:italic>\u00a0=\u00a040; 0.5\u00a0\u00b5g\/g, group D), midazolam (<jats:italic>n<\/jats:italic>\u00a0=\u00a040; 0.08\u00a0mg\/kg, group M), or normal saline (<jats:italic>n<\/jats:italic>\u00a0=\u00a040; group C). One\u2010way ANOVA with least significant difference multiple comparison test was used for multigroup comparisons of postoperative plasma levels of inflammatory cytokines and m\u2010YPAS scores. Spearman rank correlation tests were used for analyzing m\u2010YPAS scores with postoperative plasma levels of inflammatory cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma levels of tumor necrosis factor\u2010alpha (7.0\u00a0\u00b1\u00a01.6 vs. 8.1\u00a0\u00b1\u00a01.6, mean difference [95% CI]: 1.19 [0.26\u20132.11], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008) (pg\/ml) and of interleukin\u20106 (1.8\u00a0\u00b1\u00a01.2 vs. 3.3\u00a0\u00b1\u00a01.6, mean difference [95% CI]: 1.49 [0.74\u20132.25], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) (pg\/ml) and neutrophils\u2010to\u2010lymphocyte ratio (1.0\u00a0\u00b1\u00a00.5 vs. 1.5\u00a0\u00b1 0.7, mean difference [95% CI]: 0.48 [0.17\u20130.78], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) were significantly lower in group D than in group C. Furthermore, compared to group M, group D showed significantly lower plasma tumor necrosis factor\u2010alpha levels (7.0\u00a0\u00b1\u00a01.6 vs. 7.9\u00a0\u00b1\u00a01.9, mean difference [95% CI]: 0.96 [0.04\u20131.88], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04) (pg\/ml) and interleukin\u20106 levels (1.8\u00a0\u00b1\u00a01.2 vs. 2.9\u00a0\u00b1\u00a01.5, mean difference [95% CI]: 1.06 [0.31\u20131.81], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004) (pg\/ml), and neutrophil\u2010to\u2010lymphocyte ratio (1.0\u00a0\u00b1\u00a00.5 vs. 1.5\u00a0\u00b1\u00a00.6, mean difference [95% CI]: 0.42 [0.11\u20130.72], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004). Anxiety scores at postoperative 2 and 4\u00a0h in the three groups positively correlated with plasma levels of proinflammatory cytokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single preoperative intravenous dexmedetomidine dose in children undergoing same\u2010day surgery reduces postoperative systemic inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14189","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T08:30:12Z","timestamp":1617784212000},"page":"794-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The effect of dexmedetomidine premedication on postoperative systemic inflammatory response in children undergoing hernia repair surgery: A randomized controlled trial"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2688-6538","authenticated-orcid":false,"given":"Zhen","family":"Du","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Hunan Children\u2019 Hospital Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si\u2010Wei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hunan Children\u2019 Hospital Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi\u2010Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hunan Children\u2019 Hospital Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hunan Children\u2019 Hospital Changsha 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