{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:18:52Z","timestamp":1787015932464,"version":"build-2736575974"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The erector spinae plane block is a novel regional anesthetic technique that is gaining popularity in pediatrics. However, the efficacy of erector spinae plane block in children is unclear. The aim of the systematic review and meta\u2010analysis was to investigate effects of erector spinae plane block on postoperative pain relief in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched MEDLINE, Cochrane Library, EMBASE, China National Knowledge Infrastructure, and Wan fang databases for randomized controlled trials that compared erector spinae plane block with no block or other types of block in pediatric patients undergoing surgeries. The primary outcomes were pain intensity at rest within 24\u00a0h postoperatively and the number of patients requiring rescue analgesics. Data were analyzed using the fixed\u2010 or random\u2010effects model, depending on whether the heterogeneity tested by the\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0statistic was &gt;30%. We assessed the quality of evidence for the outcomes using the Grading of Recommendations, Assessment, Development, and Evaluation method.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seven randomized controlled trials involving 379 patients were reviewed. Compared with no block, erector spinae plane block slightly reduced the pain scores at 0\u00a0h (standardized mean difference [SMD]: \u22121.07; 95% confidence interval [CI]: \u22121.60 to \u22120.54;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a052%), 6\u00a0h (SMD: \u22120.82; 95% CI: \u22121.39 to \u22120.25;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a079%) postoperatively at rest and significantly reduced the need for rescue analgesics (odds ratio 0.09; 95% CI: 0.04 to 0.21;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a016%). One trial demonstrated the analgesic effect of erector spinae plane block was similar to a quadratus lumborum block, while another trial demonstrated the analgesic effect of ESPB was superior to an ilioinguinal nerve block.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review provides low\u2010quality evidence that erector spinae plane block exhibits superior analgesia compared to no block in children. Due to the limited data, evidence regarding the comparison with other regional blocks remains unclear. Future large\u2010sized and well\u2010designed randomized controlled trials are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pan.14255","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T11:54:41Z","timestamp":1626436481000},"page":"1046-1055","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effects of erector spinae plane block on postoperative pain in children undergoing surgery: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8684-3652","authenticated-orcid":false,"given":"Rong","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Anesthesiology West China Hospital, Sichuan University Chengdu Sichuan China"},{"name":"Translational Neuroscience Center Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of Education West China Second Hospital of Sichuan University Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1707-7883","authenticated-orcid":false,"given":"Weidong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiopulmonary Bypass State Key Laboratory of Cardio\u2010vascular Medicine Fuwai Hospital National Center for Cardiovascular Disease Chinese Academy of Medical Science and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology West China Hospital, Sichuan University Chengdu Sichuan China"},{"name":"Translational Neuroscience Center Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology West China Hospital, Sichuan University Chengdu Sichuan China"},{"name":"Translational Neuroscience Center Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3539-5706","authenticated-orcid":false,"given":"Yunxia","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology West China Hospital, Sichuan University Chengdu Sichuan China"},{"name":"Translational Neuroscience Center Sichuan University Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/26394"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-301378"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atc.2004.11.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anclin.2020.04.002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0000000000000451"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_9_8_1","first-page":"67","volume-title":"Searching for and selecting studies. 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