{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T09:58:00Z","timestamp":1769939880940,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T00:00:00Z","timestamp":1638144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite providing cerebral tissue oxygen saturation (StO<jats:sub>2<\/jats:sub>), the lack of quantitative information for continuous wave near\u2010infrared spectroscopy (CW\u2010NIRS) is an obstacle in evaluating cerebral hemodynamic conditions. Time\u2010domain NIRS (TD\u2010NIRS) provides both StO<jats:sub>2<\/jats:sub> and cerebral blood volume and has recently become clinically available.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate if the additional monitoring of cerebral blood volume by TD\u2010NIRS facilitates the understanding of cerebral hemodynamic conditions in patients with congenital heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preoperative TD\u2010NIRS values were retrospectively reviewed in patients who underwent a cardiac surgery or catheter examination. We compared the values between patients with single and two ventricles. Moreover, we investigated the association of these values with the demographic and clinical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in StO2 between single ventricle and two ventricles groups (median: 59.9 vs. 54.4, median difference [95% CI]: \u22124.06 [\u22129.90 to 2.90], <jats:italic>p\u00a0<\/jats:italic>=\u00a0.37). However, cerebral blood volume was significantly higher in the single ventricle group (median: 4.68 vs. 2.84, median difference [95% CI]: \u22122.01 [\u22122.88 to \u22121.06], <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001). Spearman's rank correlation analysis demonstrated an association between StO2 and postmenstrual age (r\u00a0=\u00a00.35, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.03). In contrast, cerebral blood volume was correlated with single ventricle physiology (r\u00a0=\u00a00.62, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001), postmenstrual age (r\u00a0=\u00a00.74, <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a0.001), central venous pressure (r\u00a0=\u00a00.38, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.02), and SaO2 (r\u00a0=\u00a0\u22120.38, <jats:italic>p\u00a0<\/jats:italic>=\u00a0.02). The multivariable regression analysis identified the postmenstrual age, single ventricle physiology, and SaO2 as independent factors associated with cerebral blood volume. In the logistic analysis, cerebral blood volume was identified as a significant predictor of unfavorable conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cerebral blood volume monitoring detected differences in cerebral hemodynamic conditions, related to the age and the type of ventricle physiologies. However, the differences were not apparent in StO<jats:sub>2<\/jats:sub>. The additional monitoring of cerebral blood volume by TD\u2010NIRS would facilitate a better understanding of cerebral hemodynamic conditions in patients with congenital heart disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14338","type":"journal-article","created":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T15:29:56Z","timestamp":1637335796000},"page":"413-420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical significance of assessing cerebral blood volume by time\u2010domain near\u2010infrared spectroscopy in children with congenital heart disease"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2366-7847","authenticated-orcid":false,"given":"Tomohiko","family":"Suemori","sequence":"first","affiliation":[{"name":"Department of Pediatric Intensive Care and Anesthesia Jichi Children's Medical Center Tochigi  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care and Anesthesia Jichi Children's Medical Center Tochigi  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohei","family":"Sunoki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care and Anesthesia Jichi Children's Medical Center Tochigi  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care and Anesthesia Jichi Children's Medical Center Tochigi  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7021-8510","authenticated-orcid":false,"given":"Naoyuki","family":"Taga","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care and Anesthesia Jichi Children's Medical Center Tochigi  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamoru","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care and Anesthesia Jichi Children's Medical Center Tochigi  Tochigi 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