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However, the decrement time to consciousness may not be 50%. An effect compartment concentration is associated more closely with return of consciousness than plasma concentration. An alternative decrement time, the time required for propofol to decrease to a predetermined effect compartment concentration associated with movement (eg, 2\u00a0\u00b5g.ml<jats:sup>\u22121<\/jats:sup>), was used to simulate time for the concentration to decrease from steady state at a typical targeted effect compartment concentration 3.5\u00a0\u00b5g.ml<jats:sup>\u22121<\/jats:sup> in children. These times were short and reflected a decrement time to consciousness (CST<jats:sub>AWAKE<\/jats:sub>) increase that was small with longer infusion time. CST<jats:sub>AWAKE<\/jats:sub> ranged from 7.5\u00a0min in 1\u2010year\u2010old infant given propofol for 15\u00a0min to 13.5\u00a0min in a 15\u2010year\u2010old adolescent given a 2\u2010hour infusion. Changes in decrement time with age reflect maturation of drug clearance. Neonates had prolonged increment times, 10\u00a0min after 15\u00a0min infusion and 18\u00a0min after 120\u00a0min infusion using a target concentration of 3.5\u00a0\u00b5g.ml<jats:sup>\u22121<\/jats:sup>. Decrement times to a targeted arousal concentration are context\u2010sensitive. Use of a higher target concentration of 6\u00a0\u00b5g.ml<jats:sup>\u22121<\/jats:sup> doubled decrement times. Decrement times are associated with variability: delayed recovery beyond these simulated times is likely more attributable to the use of adjuvant drugs or the child's clinical status. An understanding of propofol decrement times can be used to guide recovery after anesthesia.<\/jats:p>","DOI":"10.1111\/pan.14391","type":"journal-article","created":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T15:39:55Z","timestamp":1640965195000},"page":"396-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Propofol context\u2010sensitive decrement times in children"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7500-0062","authenticated-orcid":false,"given":"James D.","family":"Morse","sequence":"first","affiliation":[{"name":"Department of Pharmacology &amp; Clinical Pharmacology Auckland University  Auckland New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8544-8768","authenticated-orcid":false,"given":"Luis Ignacio","family":"Cortinez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n 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