{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:57:20Z","timestamp":1792180640709,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The goal of the present study was to investigate intraoperative factors associated with major neurological complications at 1\u00a0year following surgery for necrotizing enterocolitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and Methods<\/jats:title><jats:p>The study consisted of a retrospective review of medical charts of patients operated for over one calendar year in one institution. Data collected included demographic data, cardiac resuscitation at birth, Bell classification, antibiotics usage, time of day of surgery, surgical technique, surgical duration, type of ventilation, intraoperative vasoactive agents, and albumin use, nadir cerebral saturation, the decrease in cerebral saturation from baseline, the time period when cerebral saturation was at least 20% below baseline, and the mean arterial pressure at nadir cerebral saturation. Reported follow\u2010up complications were assessed during formal neonatologist consultation and additional imaging exploration as needed. Analyses included descriptive statistics, and univariable and multivariable statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 32 patients with no prior clinical neurological complications, of which 25\u00a0had normal cerebral imaging. Severe neurological complications occurred in nine patients at 1\u00a0year: Intraventricular hemorrhage (<jats:italic>N<\/jats:italic>\u00a0=\u00a02) and Periventricular leukomalacia (<jats:italic>N<\/jats:italic>\u00a0=\u00a07). However, preoperative cerebral imaging was lacking in seven patients. Consequently, the observed neurological complications at 1\u00a0year might be present before the surgery. Multivariable analysis found the decrease in cerebral saturation \u226536% from baseline as the only factor associated with the occurrence of those complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intraoperative decrease of cerebral oxygen saturation below \u226536% from baseline is associated with severe neurological complications in neonates undergoing surgery for necrotizing enterocolitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14392","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T08:05:03Z","timestamp":1641369903000},"page":"421-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Intraoperative cerebral oxygen saturation and neurological outcomes following surgical management of necrotizing enterocolitis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1703-2338","authenticated-orcid":false,"given":"Florence","family":"Julien\u2010Marsollier","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Paris  Paris France"},{"name":"Department of Anesthesia and Intensive care Robert Debr\u00e9 University Hospital  Paris France"},{"name":"University Hospital Federation I2\u2010D2, INSERM U1141 Robert Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementine","family":"Cholet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris  Paris France"},{"name":"Department of Anesthesia and Intensive care Robert Debr\u00e9 University Hospital  Paris France"},{"name":"University Hospital Federation I2\u2010D2, INSERM U1141 Robert Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Coeffic","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris  Paris France"},{"name":"Department of Anesthesia and Intensive care Robert Debr\u00e9 University Hospital  Paris France"},{"name":"University Hospital Federation I2\u2010D2, INSERM U1141 Robert Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Dupont","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris  Paris France"},{"name":"Department of Anesthesia and Intensive care Robert Debr\u00e9 University Hospital  Paris France"},{"name":"University Hospital Federation I2\u2010D2, INSERM U1141 Robert Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris  Paris France"},{"name":"Department of Anesthesia and Intensive care Robert Debr\u00e9 University Hospital  Paris France"},{"name":"University Hospital Federation I2\u2010D2, INSERM U1141 Robert Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Loiselle","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris  Paris France"},{"name":"Department of Anesthesia and Intensive care Robert Debr\u00e9 University Hospital  Paris France"},{"name":"University Hospital Federation I2\u2010D2, INSERM U1141 Robert Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Brouns","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris  Paris France"},{"name":"Department of Anesthesia and Intensive care Robert Debr\u00e9 University Hospital  Paris France"},{"name":"University Hospital Federation I2\u2010D2, INSERM U1141 Robert Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Bonnard","sequence":"additional","affiliation":[{"name":"Department of general and urological surgery Robert Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Biran","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris  Paris France"},{"name":"University Hospital Federation I2\u2010D2, INSERM U1141 Robert Debr\u00e9 University Hospital  Paris France"},{"name":"Department of Neonatology Robert Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Brasher","sequence":"additional","affiliation":[{"name":"Department of Anesthesia &amp; Pain Management Royal Children\u2019s Hospital  Melbourne Australia"},{"name":"Anesthesia and Pain Management Research Group Murdoch Children\u2019s Research Institute  Melbourne Australia"},{"name":"Centre for Integrated Critical Care University of Melbourne  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1577-1030","authenticated-orcid":false,"given":"Souhayl","family":"Dahmani","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris  Paris France"},{"name":"Department of Anesthesia and Intensive care Robert Debr\u00e9 University Hospital  Paris France"},{"name":"University Hospital Federation I2\u2010D2, INSERM U1141 Robert Debr\u00e9 University Hospital  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2019.06.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.02.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2016.05.012"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-69912013000500003"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-317830"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.11.011"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1387942"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-16915130"},{"key":"e_1_2_8_10_1","volume-title":"StatPearls","author":"Starr R","year":"2021"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpme.1987.15.4.333"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2017.08.015"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184993"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/chd.12426"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600597"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2015.11.004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051879"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2015.06.005"},{"issue":"3","key":"e_1_2_8_19_1","first-page":"e13875","article-title":"Near\u2010infrared spectroscopy monitoring in pediatric anesthesiology: a pro\u2010con discussion","volume":"13","author":"Rao A","year":"2021","journal-title":"Cureus"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-016-0274-2"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.12.042"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000268712.00756.dd"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-0973"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12671"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2020.05.003"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.2.337"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001348"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12622"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2014-307919"},{"key":"e_1_2_8_30_1","first-page":"46","article-title":"Monitoring cerebral oxygenation in neonates: an update","volume":"5","author":"Dix LM","year":"2017","journal-title":"Front Pediatr"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.14463"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001920"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12698"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.14392","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pan.14392","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.14392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T16:06:20Z","timestamp":1693152380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.14392"}},"subtitle":["Predictive factors of neurological complications following neonatal necrotizing enterocolitis"],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/pan.14392"],"URL":"https:\/\/doi.org\/10.1111\/pan.14392","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]},"assertion":[{"value":"2021-07-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}