{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:53:25Z","timestamp":1788926005007,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:00:00Z","timestamp":1647388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is increasing interest in two\u2010agent single\u2010pump intravenous infusions for anesthesia and sedation in pediatric patients. Propofol\u2013remifentanil is one such mixture.<\/jats:p><jats:p>The poor miscibility of such admixtures when remifentanil is added in very high concentrations and when the admixtures are maintained in static conditions has been demonstrated; however, these physiochemical properties have not been examined in clinically relevant concentrations or settings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine if propofol\u2013remifentanil admixtures maintain consistent remifentanil delivery when mixed in clinically relevant remifentanil concentrations and subjected to the physical effects of an actively infusing, directly\u2010engaged syringe driver system with an extension line, as occurs when propofol\u2013remifentanil is administered to a patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A propofol 10\u00a0mg.ml<jats:sup>\u22121<\/jats:sup> combined with remifentanil 5 mcg.ml<jats:sup>\u22121<\/jats:sup> solution was run using a Paedfusor<jats:sup>\u00ae<\/jats:sup> propofol target\u2010controlled infusion model for 10\u00a0kg and 20\u00a0kg children for 57\u00a0min at a target plasma concentration of 3 mcg.ml<jats:sup>\u22121<\/jats:sup> through a 30\u00a0ml syringe, 180\u00a0cm minimum volume extension line, lever lock cannula, interlink injection site, and 22\u00a0g intravenous cannula into sample pots. Samples were taken at the completion of the loading bolus, 1 and 2\u00a0min postcompletion of loading bolus, and every 5\u00a0min thereafter. The remifentanil concentration in these samples was then assayed using chromatography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in the concentration of remifentanil in the samples based on the duration of infusion to the endpoint of 1\u00a0h, or on the patient weight model used. The concentration remained 5 mcg.ml<jats:sup>\u22121<\/jats:sup> +\/\u2212 0.5 mcg.ml<jats:sup>\u22121<\/jats:sup> per sample. The measurement uncertainty for the assay at 0.5 mcg.ml<jats:sup>\u22121<\/jats:sup> is +\/\u2212 0.2 mcg.ml<jats:sup>\u22121<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The concentration of remifentanil was 5 mcg.ml<jats:sup>\u22121<\/jats:sup> +\/\u2212 0.5 mcg.ml<jats:sup>\u22121<\/jats:sup> and was consistent across 57\u00a0min of infusion, and two different pediatric weight profiles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14427","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T10:18:40Z","timestamp":1646216320000},"page":"727-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Consistency of remifentanil concentrations in propofol\u2013Remifentanil infusions. 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