{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:29:21Z","timestamp":1790231361306,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012234","name":"Shenzhen Peacock Plan","doi-asserted-by":"publisher","award":["20210830100C"],"award-info":[{"award-number":["20210830100C"]}],"id":[{"id":"10.13039\/501100012234","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012234","name":"Shenzhen Peacock Plan","doi-asserted-by":"publisher","award":["20210802658C"],"award-info":[{"award-number":["20210802658C"]}],"id":[{"id":"10.13039\/501100012234","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Major anesthetic risks arise in orthopedic surgeries for children with osteogenesis imperfecta, a rare genetically inherited condition presenting diverse skeletal issues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to investigate anesthetic risks, including difficult airway, hypo\u2010 and hyperthermia, blood loss, and pain, in connection with patient, anesthetic, and surgical factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Both descriptive and inferential statistics were employed to study the anesthetic risks and their predictors. Data of 252 surgeries for 132 Chinese osteogenesis imperfecta patients aged 18 or below were retrieved from the authors' hospital between 2015 and 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two thirds of the cohort were Sillence type IV patients, with types I, III, and V accounting for 7.6%, 14.4%, and 11.4%, respectively. Video and direct laryngoscopy were used. No case of difficult airway was identified. Due to a careful management strategy, intraoperative temperature varied on average between \u22120.38\u00b0C and +0.89\u00b0C from the initial temperature. Fifty\u2010two and 18 cases of hyper\u2010 and hypothermia were encountered, respectively. The use of sevoflurane for maintenance resulted in a mean increase of +0.24\u00b0C [95% CI 0.05\u2009~\u20090.42] in the maximum temperature. Massive blood losses (&gt;20% of estimated total blood volume) were observed in 18.3% of the cases. Neither intraoperative temperature changes nor blood loss was found to be related to Sillence classification. Regional anesthesia techniques were applied to 72.6% of the cases. Ultrasound guidance was used per the judgment of anesthesiologists or when in case of difficult landmarks. The incidence of difficult regional anesthesia was low (4 out of 252). For postoperative analgesia, 154 neuraxial blocks (including 77 caudal and 77 lumbar epidural) and 29 peripheral nerve blocks were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anesthesia for children with osteogenesis imperfecta undergoing complex orthopedic procedures was challenging. Proper anesthesia planning was essential for both intraoperative management and postoperative analgesia. Age, surgical duration, and use of sevoflurane for maintenance impacted the intraoperative temperature most, and massive blood loss was not uncommon. The risks for airway or regional anesthesia difficulties were low. Pain scores could be controlled to be \u22643 via multiple techniques.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14454","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T07:27:02Z","timestamp":1649230022000},"page":"851-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Comprehensive risk assessments and anesthetic management for children with osteogenesis imperfecta: A retrospective review of 252 orthopedic procedures over 5\u2009years"],"prefix":"10.1111","volume":"32","author":[{"given":"Xiyun","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The University of Hong Kong \u2013 Shenzhen Hospital (HKU\u2010SZH)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1880-0893","authenticated-orcid":false,"given":"Peikai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics The University of Hong Kong \u2013 Shenzhen Hospital (HKU\u2010SZH)  Shenzhen China"},{"name":"School of Biomedical Sciences The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The University of Hong Kong \u2013 Shenzhen Hospital (HKU\u2010SZH)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The University of Hong Kong \u2013 Shenzhen Hospital (HKU\u2010SZH)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics The University of Hong Kong \u2013 Shenzhen Hospital (HKU\u2010SZH)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2295-5169","authenticated-orcid":false,"given":"Zhijia","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics The University of Hong Kong \u2013 Shenzhen Hospital (HKU\u2010SZH)  Shenzhen China"},{"name":"Department of Orthopedics and Traumatology The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hechun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The University of Hong Kong \u2013 Shenzhen Hospital (HKU\u2010SZH)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yapeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics The University of Hong Kong \u2013 Shenzhen Hospital (HKU\u2010SZH)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics The University of Hong Kong \u2013 Shenzhen Hospital (HKU\u2010SZH)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6853-0591","authenticated-orcid":false,"given":"Michael Kai\u2010tsun","family":"To","sequence":"additional","affiliation":[{"name":"Department of Pediatric Orthopedics The University of Hong Kong \u2013 Shenzhen Hospital (HKU\u2010SZH)  Shenzhen China"},{"name":"Department of Orthopedics and Traumatology The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5463-5763","authenticated-orcid":false,"given":"Qiang","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology The University of Hong Kong \u2013 Shenzhen Hospital (HKU\u2010SZH)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00728-X"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199908150-00008"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20429"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-198903000-00014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200210000-00039"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16051-0"},{"issue":"5","key":"e_1_2_10_8_1","first-page":"113","article-title":"Clinical variability in osteogenesis imperfecta\u2010variable expressivity or genetic heterogeneity","volume":"15","author":"Sillence DO","year":"1979","journal-title":"Birth Defects Orig Artic Ser"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1968"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4377-0755-7.00001-4"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.52"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-019-1197-z"},{"key":"e_1_2_10_13_1","first-page":"CD005088","article-title":"Bisphosphonate therapy for osteogenesis imperfecta","volume":"7","author":"Dwan K","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.86.5.356"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.82B1.0820011"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e3282f35f03"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.1992.tb00186.x"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13504"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1996.tb12619.x"},{"issue":"3","key":"e_1_2_10_20_1","first-page":"202","article-title":"Caudal block in a child with osteogenesis imperfecta, type II","volume":"5","author":"Barros F","year":"1995","journal-title":"Paediatr Anaesth"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1213\/XAA.0000000000000527"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40140-017-0207-8"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13440"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0000000000001105"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e3283459616"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.36303\/SAJAA.2020.26.1.2324"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2022.816078"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36545"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059569"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm-2020-101576"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000227155.44286.28"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-199414060-00021"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-199807000-00019"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.49.3.375"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199904000-00044"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.14454","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pan.14454","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.14454","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:28:16Z","timestamp":1692872896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.14454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/pan.14454"],"URL":"https:\/\/doi.org\/10.1111\/pan.14454","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"2021-08-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}