{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:58Z","timestamp":1759336318262,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001136","name":"Australian and New Zealand College of Anaesthetists","doi-asserted-by":"publisher","award":["2011 project grant"],"award-info":[{"award-number":["2011 project grant"]}],"id":[{"id":"10.13039\/501100001136","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011528","name":"Phase One Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011528","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Intravenous acetaminophen and opioid analgesics are routinely given concurrently to children after major surgery, where intravenous access can be limited. There is limited information about the compatibility of acetaminophen with opioid analgesics and ketamine in concentrations commonly used in pediatric setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to determine the physical and chemical compatibility in mixtures of intravenous acetaminophen 10\u00a0mg\/mL with morphine (0.025, 0.05, 0.1, 0.2, 1, and 2\u00a0mg\/ml), fentanyl (0.5, 0.75, 1, 1.5, 2, and 5\u00a0mcg\/ml) and ketamine (0.01, 0.1, 0.5, 1, 1.5, and 3\u00a0mg\/ml).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Acetaminophen was mixed with all 18 solutions and was examined at time 0, 15, 30, and 60\u2009min. In Phase one of the study, we used a colorimetric method to assess preliminary feasibility and acetaminophen recovery. In Phase two study, we used high\u2010performance liquid chromatography to evaluate the recovery of all components of the mixtures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All solutions tested, for both acetaminophen and the three analgesics, had more than 90% of the drug recovery, up to 60\u2009min after mixing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data demonstrated the stability of acetaminophen, in combination with fentanyl, morphine, and ketamine at clinical concentrations used in acute pediatric pain setting.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14455","type":"journal-article","created":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T14:49:25Z","timestamp":1649602165000},"page":"862-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Compatibility of intravenous acetaminophen with morphine, fentanyl and ketamine in acute pediatric pain setting"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3820-5063","authenticated-orcid":false,"given":"Edmond","family":"O'Loughlin","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Pain and Perioperative Medicine Fiona Stanley and Fremantle Hospital Group  Murdoch WA Australia"},{"name":"School of Medicine University of Western Australia  Murdoch WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2628-8810","authenticated-orcid":false,"given":"Yan Ghee","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Fiona Stanley and Fremantle Hospital Group  Murdoch WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5883-6415","authenticated-orcid":false,"given":"Angela","family":"Cheaib","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Fiona Stanley and Fremantle Hospital Group  Murdoch WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3574-7855","authenticated-orcid":false,"given":"Matthew T. V.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care The Chinese University of Hong Kong  Hong Kong Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7548-1003","authenticated-orcid":false,"given":"Robin","family":"Williams","sequence":"additional","affiliation":[{"name":"PathWest LMWA FSH Network  Murdoch WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4,24]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"907","volume-title":"APM:SE Working Group of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine (2020), Acute pain management: scientific evidence (5th edition)","author":"Schug SASD","year":"2020"},{"key":"e_1_2_9_3_1","unstructured":"PERFALGAN (Paracetamol) Solution for infusion. NOBLE PARK (VIC): Bristol\u2010Myers Squibb Australia Pty ltd;2012."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0b013e328319c04b"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1310\/hpj4901-42"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/ait.2020.92684"},{"key":"e_1_2_9_7_1","unstructured":"Convention USP.The united StatesPharmacopeia\/the National Formulary USP 26\/NF 21. United States Pharmacopeial Convention Inc;2003."},{"volume-title":"ASHP Injectable Drug Information","year":"2022","author":"McEvoy G","key":"e_1_2_9_8_1"},{"volume-title":"King Guide to Parenteral Admixtures","year":"2022","key":"e_1_2_9_9_1"},{"volume-title":"DRUGDEX System","year":"2022","author":"Compatibility I","key":"e_1_2_9_10_1"},{"volume-title":"Australian Injectable Drugs Handbook","year":"2022","author":"Symons K","key":"e_1_2_9_11_1"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12647"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.5530\/phm.2015.6.5"},{"key":"e_1_2_9_14_1","unstructured":"Paracetamol Kabi.Mount Kuring\u2010Gai (NSW): fresenius kabi Australia Pty Limited.2018."},{"key":"e_1_2_9_15_1","unstructured":"PARACETAMOL IV PFIZER\u00ae. Pfizer Australia Pty Ltd Australia.2020."},{"key":"e_1_2_9_16_1","unstructured":"Paracetamol BNM Solution For Infusion. North Sydney (NSW): Boucher & Muir Pty Ltd Australia.2017."},{"key":"e_1_2_9_17_1","unstructured":"Paracetamol AN. South yarra (vic): amneal pharma australia Pty Ltd 2015."},{"key":"e_1_2_9_18_1","unstructured":"PARACETAMOL \u2013 AFT (Paracetamol) solution for infusion. North ryde (NSW): AFT pharmaceuticals Pty Ltd Australia.2019."}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.14455","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pan.14455","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.14455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T10:28:13Z","timestamp":1692872893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.14455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,24]]},"references-count":17,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/pan.14455"],"URL":"https:\/\/doi.org\/10.1111\/pan.14455","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"type":"print","value":"1155-5645"},{"type":"electronic","value":"1460-9592"}],"subject":[],"published":{"date-parts":[[2022,4,24]]},"assertion":[{"value":"2021-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}