{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T16:45:58Z","timestamp":1789231558899,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anorectal malformations are one of the most frequent congenital malformations treated by pediatric surgeons. In low\u2010income countries, the surgical and anesthetic management of children in need of these procedures can be challenging. Limited oxygen supply, lack of equipment, especially pediatric, and intensive care units make the use of regional anesthesia appealing. We present a series of four cases of anorectal malformations corrections in Guinea Bissau, in children up to 13\u2009months of age, under regional anesthesia and sedation with ketodex, a mixture of ketamine and dexmedetomidine (in a proportion of 1\u00a0mg to 1\u00a0\u03bcg). No child developed respiratory depression requiring airway intervention or supplemental oxygen, or had hemodynamic instability.<\/jats:p>","DOI":"10.1111\/pan.14465","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T08:53:34Z","timestamp":1650531214000},"page":"278-281","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp>Ketamine\u2010dexmedetomidine<\/scp> combination for sedation in pediatric major surgery in a low\u2010income country"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5183-2585","authenticated-orcid":false,"given":"Sofia","family":"Vila Moutinho Tavares","sequence":"first","affiliation":[{"name":"Department of Anesthesiology 1 Centro Hospitalar Universit\u00e1rio do Algarve  Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0932-1033","authenticated-orcid":false,"given":"Jo\u00e3o C.","family":"Tavares","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology 1 Centro Hospitalar Universit\u00e1rio do Algarve  Faro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Borges Marques","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hospital de Braga  Braga Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Teixeira de Figueiredo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hospital da Luz  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Lucas","family":"Passos de Souza","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hospital das Cl\u00ednicas da Faculdade de Medicina de Ribeir\u00e3o Preto, HCFMRP\u2010USP  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2019.00007"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2006.04907.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/LRA.S236550"},{"key":"e_1_2_7_5_1","first-page":"38","article-title":"A new approach for procedural sedation in children: the intra\u2010muscular dextroketamine and dexmedetomidine association","volume":"6","author":"Lucas RPS","year":"2019","journal-title":"J Anesth Clin Care"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2897"},{"issue":"1","key":"e_1_2_7_7_1","first-page":"1","article-title":"Anesthesia and underdeveloped countries","volume":"55","author":"Bharati SJ","year":"2014","journal-title":"Niger Med 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