{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:17:55Z","timestamp":1787015875809,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T00:00:00Z","timestamp":1667779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acetaminophen is routinely used for perioperative analgesia in children undergoing major surgical procedures. There are few estimates of acetaminophen pharmacokinetic parameters in children with congenital heart disease, especially those with cyanotic heart disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The current study prospectively investigated differences in acetaminophen pharmacokinetics following surgery using cardiopulmonary bypass in children with cyanotic and acyanotic congenital heart disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Children (2\u20136\u2009years, 9\u201323\u2009kg) presenting for median sternotomy for Fontan palliation (cyanotic patients) or two ventricle surgical repair (acyanotic patients) were eligible for inclusion. A single intravenous dose of acetaminophen (15\u2009mg\/kg) was administered at the start of sternal closure after separation from cardiopulmonary bypass. The time\u2010course of acetaminophen concentrations were described using non\u2010linear mixed effects models. One and two\u2010compartment disposition models with first\u2010order elimination were tested. Pharmacokinetic parameter estimates were scaled using allometry and standardized to a 70\u2009kg person.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 208 acetaminophen concentrations assayed from 30 children, 15 with cyanotic, and 15 with acyanotic heart disease. A 2\u2010compartment model best described acetaminophen PK. Parameter estimates (population parameter variability, PPV%; 95% confidence interval, CI) were clearance CL 15.3\u00a0L.h\u20101.70\u2009kg\u20101 (22.2%; 13.8\u201316.7), intercompartment clearance Q 45.4\u00a0L.h\u20101.70\u2009kg\u20101 (22.4%; 25.2\u201361.9), central volume of distribution V1 33.5\u00a0L.70\u2009kg\u20101 (23.2%; 25.9\u201338.8), peripheral volume of distribution V2 32.1\u00a0L.70\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      (21.7%; 25.9\u201338.8). Neither clearance nor volume parameters differed between cyanotic and acyanotic patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Acetaminophen pharmacokinetics were characterized using a 2\u2010compartment model with first\u2010order elimination following cardiac bypass surgery in children. Population pharmacokinetic parameter estimates were similar to other studies in children. No differences were detected between patients with cyanotic and acyanotic heart disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pan.14579","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T10:18:13Z","timestamp":1666261093000},"page":"46-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acetaminophen pharmacokinetics in infants and children with congenital heart disease"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0112-311X","authenticated-orcid":false,"given":"Jay","family":"Holladay","sequence":"first","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8183-8507","authenticated-orcid":false,"given":"Peter","family":"Winch","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Anesthesiology &amp; Pain Medicine The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7500-0062","authenticated-orcid":false,"given":"James","family":"Morse","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Auckland  Auckland New\u00a0Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2826-3019","authenticated-orcid":false,"given":"Brian J.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology University of Auckland  Auckland New\u00a0Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"McKee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Anesthesiology &amp; Pain Medicine The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Rice\u2010Weimer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph D.","family":"Tobias","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Anesthesiology &amp; Pain Medicine The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/apc.APC_190_18"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-013-0062-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.148050"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2005.01455.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.2000.00231.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200206000-00012"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199630050-00001"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199529050-00001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.2002.00616.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.48.113006.094708"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/psp4.12161"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-007-9081-1"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-011-9255-z"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1214\/ss\/1177013815"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-2607(98)00098-4"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1373"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/15748847113089990067"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcan.2002.29690"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.4.1020"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1980.tb01812.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-198207020-00001"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.104736"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.24.25"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181f9b3a0"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02022.x"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13230"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.14579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pan.14579","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.14579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T18:52:18Z","timestamp":1692471138000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.14579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,7]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1111\/pan.14579"],"URL":"https:\/\/doi.org\/10.1111\/pan.14579","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,7]]},"assertion":[{"value":"2022-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}