{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:14:31Z","timestamp":1791980071401,"version":"4.4.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Resuscitation with blood products is often required for pediatric cardiac surgery patients following cardiopulmonary bypass. However, data suggest that blood product transfusion is an independent predictor of adverse outcomes. Most studies have specifically found detrimental effects of overall transfusion of red blood cells in particular, but few have analyzed outcomes by the other specific blood product components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The objective of this study is to analyze adverse outcomes associated with intraoperative transfusion of specific blood product components.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review was performed on 643 pediatric patients who underwent cardiac surgery requiring cardiopulmonary bypass to evaluate the risk of selected adverse outcomes associated with intraoperative blood product transfusion. Adverse outcomes included thrombotic complications, stroke, acute kidney injury, prolonged mechanical ventilation, and death. Univariate logistic and linear regression analyses were performed to explore the association between various blood products and the occurrence of postoperative complications. Multiple logistic and linear regression analyses were performed adjusting for age, cyanotic status, The\u00a0Society\u00a0of\u00a0Thoracic\u00a0Surgeons\u2010European\u00a0Association\u00a0for\u00a0Cardio\u2010Thoracic\u00a0Surgery\u00a0Score\u00a0(STAT score), and cardiopulmonary bypass time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Unadjusted analysis using univariate logistic and linear regressions showed statistically significant associations of almost all blood components (per 10\u00a0mL\/kg dose increments) with multiple postoperative complications, including mortality, thrombotic complications, stroke, and days of mechanical ventilation. After adjusting for patient age, cyanotic status, STAT score, and cardiopulmonary bypass time, multivariable logistic and linear regression analyses revealed no association between transfusion of blood products with acute kidney injury and stroke. Administration of red blood cells was the only category significantly correlated with increased days of mechanical ventilation (0.5\u2009days increase in mechanical ventilation per 10\u00a0mL\/kg transfusion of red\u00a0blood\u00a0cells). The only blood product to show complete lack of a statistically significant association with any of the studied outcomes was cryoprecipitate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transfusion of blood products following cardiopulmonary bypass is associated with postoperative adverse outcomes. Future studies aimed at strategies to reduce intraoperative bleeding and decrease the amount of blood products administered are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pan.14637","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T09:26:23Z","timestamp":1674638783000},"page":"387-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Intraoperative blood product transfusion in pediatric cardiac surgery patients: A retrospective review of adverse outcomes"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0689-8494","authenticated-orcid":false,"given":"Christopher","family":"Busack","sequence":"first","affiliation":[{"name":"Division of Anesthesiology, Pain and Perioperative Medicine Children's National Hospital  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Sohel","family":"Rana","sequence":"additional","affiliation":[{"name":"Children's National Hospital, Joseph E. Robert, Jr., Center for Surgical Care  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Beidas","sequence":"additional","affiliation":[{"name":"Eastern Virginia Medical School  Norfolk Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Miguel","family":"Almirante","sequence":"additional","affiliation":[{"name":"The George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7137-4737","authenticated-orcid":false,"given":"Nina","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Division of Cardiac Anesthesia, Children's National Hospital The George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Matisoff","sequence":"additional","affiliation":[{"name":"Division of Cardiac Anesthesia, Children's National Hospital The George Washington University School of Medicine and Health Sciences  Washington District of Columbia 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