{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:43:52Z","timestamp":1787611432170,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,7,23]],"date-time":"2023-07-23T00:00:00Z","timestamp":1690070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Neonatal surgical mortality continues to be high in developing countries. A better understanding of perioperative events and optimization of causative factors can help in achieving a favorable outcome. The present study was designed to evaluate the perioperative course of surgical neonates and find out potential factors contributing to postoperative mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective observational study enrolled neonates, undergoing emergency surgical procedures in a tertiary care institute. Primary outcome was 6\u2009weeks postsurgical mortality. The babies were observed till discharge and subsequently followed up telephonically for 6\u2009weeks after surgery. Multivariable logistic regression analysis of various parameters was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of the 324 neonates who met inclusion criteria, 278 could be enrolled. The median age was 4\u2009days. Sixty\u2010two (27.7%) neonates were born before 37\u2009weeks period of gestation (POG), and 94 (41.8%) neonates weighed below 2.5\u2009kg. The most common diagnoses was trachea\u2010esophageal fistula (29.9%) and anorectal malformation (14.3%). The median duration of hospital stay for survivors was 14\u2009days. The in\u2010hospital mortality was 34.8%. Mortality at 6\u2009weeks following surgery was 36.2%. Five independent risk factors identified were POG\u2009&lt;\u200934\u2009weeks, preoperative oxygen therapy, postoperative inotropic support postoperative mechanical ventilation, and postoperative leukopenia. In neonates where invasive ventilation was followed by non\u2010invasive positive pressure ventilation in the postoperative period, risk of postoperative surgical mortality was significantly reduced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Present study identified preterm birth, preoperative oxygen therapy, postoperative positive pressure ventilation, requirement of inotropes, and postoperative leukopenia as independent predictors of 6\u2010week mortality. The possibility of early switch to noninvasive positive pressure ventilation was associated with a reduction in neonatal mortality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14731","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T06:13:58Z","timestamp":1690179238000},"page":"1075-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Postoperative outcome of neonatal emergency surgeries in a tertiary care institute\u2014A prospective observational study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3297-4358","authenticated-orcid":false,"given":"Sunaakshi","family":"Puri","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive care Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indu Mohini","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive care Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neerja","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive care Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-4377","authenticated-orcid":false,"given":"Sandhya","family":"Yaddanapudi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive care Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preethy J.","family":"Mathew","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive care Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjishnujit","family":"Bandyopadhyay","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive care Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Samujh","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8798-0205","authenticated-orcid":false,"given":"Shivani","family":"Dogra","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neonatology Post Graduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,7,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/jiaps.JIAPS_30_18"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-69912013000500003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0189-6725.120886"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0191176"},{"key":"e_1_2_10_6_1","first-page":"377","volume-title":"Cloherty and Stark's Manual of Neonatal Care","author":"Eichenwald EC","year":"2016"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.19-6-e322"},{"key":"e_1_2_10_8_1","unstructured":"American Society of Anesthesiologists'(ASA) ASA Physical Status Classification System.2020. 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