{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T16:24:04Z","timestamp":1789403044312,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T00:00:00Z","timestamp":1691020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We evaluated the correlation between regional oxygen saturation (rSO<jats:sub>2<\/jats:sub>) in the frontal and right renal dorsum (cerebral rSO<jats:sub>2<\/jats:sub> and somatic rSO<jats:sub>2<\/jats:sub>) measured by near\u2010infrared spectroscopy (INVOS\u2122 5100C, Medtronic) and central venous oxygen saturation (ScvO<jats:sub>2<\/jats:sub>) measured with a fiber\u2010optic oximetry catheter (PediaSat\u2122, Edwards Lifesciences) during surgery in order to determine whether noninvasive rSO<jats:sub>2<\/jats:sub> could be used as an alternative to ScvO<jats:sub>2<\/jats:sub> in pediatric cardiac surgery patients. We evaluated the correlation between regional tissue oxygen saturation (cerebral rSO<jats:sub>2<\/jats:sub> and somatic rSO<jats:sub>2<\/jats:sub>) measured by near\u2010infrared spectroscopy and other patient measures with central venous oxygen saturation (ScvO<jats:sub>2<\/jats:sub>) measured with a fiber\u2010optic oximetry catheter to track global oxygen supply demand as a potential alternative or supplement to ScvO<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This single\u2010center prospective observational study enrolled 33 children (weight\u2009&lt;\u200910\u2009kg) who underwent cardiac surgery for congenital heart disease between February 2018 and November 2021. ScvO<jats:sub>2<\/jats:sub>, cerebral rSO<jats:sub>2<\/jats:sub>, and somatic rSO<jats:sub>2<\/jats:sub> were recorded simultaneously after anesthesia induction and central venous catheter placement. Pearson's correlation coefficient and Bland\u2013Altman analysis were used to determine the relationship between ScvO<jats:sub>2<\/jats:sub> and rSO<jats:sub>2<\/jats:sub>. We conducted correlation, Bland Altman, and multiple regression analyses to identify associations between rSO<jats:sub>2<\/jats:sub>, patient measures, and ScvO<jats:sub>2<\/jats:sub> values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients' median age was 11.0 (quartile 2.0\u201316.0) months. Their weight was 7.2 (quartile 4.5\u20139.2) kg. Cerebral rSO<jats:sub>2<\/jats:sub> was significantly positively correlated with ScvO<jats:sub>2<\/jats:sub> (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.29, <jats:italic>p<\/jats:italic>\u2009=\u2009.002 in all patients; <jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.61, <jats:italic>p<\/jats:italic>\u2009=\u2009.013 in the patients without mixing at the atrial level), whereas somatic rSO<jats:sub>2<\/jats:sub> was not. The Bland\u2013Altman analysis demonstrated biases [95% confidence interval; 95% CI] (lower and upper limits of agreement [95% CI]) of 0.27% [\u22124.26 to 4.80] (\u221224.79 [\u221232.61 to \u221216.96] to 25.33 [17.50 to 33.16]) between cerebral rSO<jats:sub>2<\/jats:sub> and ScvO<jats:sub>2<\/jats:sub> and 0.91% [\u22125.48 to 7.30] (\u221234.43 [\u221245.47 to \u221223.39] to 36.25 [25.21 to 47.29]) between somatic rSO<jats:sub>2<\/jats:sub> and ScvO<jats:sub>2<\/jats:sub>. Preoperative brain natriuretic peptide (BNP) and SpO<jats:sub>2<\/jats:sub> were independent variables associated with ScvO<jats:sub>2<\/jats:sub> and cerebral and somatic rSO<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Cerebral rSO<jats:sub>2<\/jats:sub>, SpO<jats:sub>2<\/jats:sub>, and BNP were significantly correlated with ScvO<jats:sub>2<\/jats:sub>, although the cerebral rSO<jats:sub>2<\/jats:sub> correlation was greater for lesions without atrial mixing. rSO<jats:sub>2<\/jats:sub>, BNP, and SpO<jats:sub>2<\/jats:sub> might be used to track changes in ScvO<jats:sub>2<\/jats:sub> but cerebral rSO<jats:sub>2<\/jats:sub> is not sufficiently precise to replace it.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14741","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T11:53:57Z","timestamp":1691063637000},"page":"913-922","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association between regional oxygen saturation and central venous saturation in pediatric patients undergoing cardiac surgery: A prospective observational study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1364-3326","authenticated-orcid":false,"given":"Naoki","family":"Hirai","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6040-4926","authenticated-orcid":false,"given":"Junichi","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishiko","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Hashiba","sequence":"additional","affiliation":[{"name":"Division of Intensive Care Unit Hirosaki University Hospital  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuyoshi","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Hirosaki University Graduate School of Medicine  Hirosaki Japan"},{"name":"Department of Perioperative Medicine for Community Healthcare Hirosaki University Graduate School of Medicine  Hirosaki Japan"},{"name":"Department of Perioperative Stress Management Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(97)70074-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-015-9757-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318233056e"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181a63e0c"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2337-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.08.048"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.12122"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-019-00260-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-020-01733-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02783.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2010.547961"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14146"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-011-9960-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-018-0184-6"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2008.02.013"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181fef34e"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.04.018"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)02632-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112455"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000872"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.092"}],"container-title":["Pediatric 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