{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:51:09Z","timestamp":1747187469237,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite preventive strategies, vomiting is an adverse event affecting patients with cancer. However, literature on the incidence and risk factors for vomiting in pediatric patients with cancer are scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the incidence and risk factors for vomiting within 24\u2009h and goodness of fit for the Eberhart score in pediatric patients with hematologic cancers after receiving intrathecal chemotherapy under deep sedation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study included patients under 20\u2009years of age with hematologic cancers who were scheduled to undergo intrathecal chemotherapy under anesthesia. The primary outcome was the occurrence of vomiting within 24\u2009h after the end of anesthesia. Sociodemographic and procedure data and underlying diseases were collected. Patients were monitored during the procedure, in the postanesthesia care unit, and the day after (by phone call).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 139 patients were included, and the incidence of vomiting was 30.9% within 24\u2009h after intrathecal chemotherapy under anesthesia, with 90.7% of vomiting prior to 6\u2009h. Prophylactic ondansetron was administered prior to the procedure to 45.3% of patients. Risk factors for vomiting were female gender (hazard ratio: 2.47, 95% confidence interval: 1.35\u20134.53, <jats:italic>p<\/jats:italic>: .003), consolidation phase of treatment (hazard ratio: 2.16, 95% confidence interval: 1.10\u20134.24, <jats:italic>p<\/jats:italic>: .025), and history of kinetosis (hazard ratio: 2.49, 95% confidence interval: 1.31\u20134.70, <jats:italic>p<\/jats:italic>: .005). Incidence of vomit was higher than estimated by the Eberhart score distribution (observed incidence in patients with a score of zero: 33.3%; with a score of one: 28.8%; with a score of two: 60%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A high incidence of vomiting was observed within 24\u2009h after intrathecal chemotherapy under propofol deep sedation. Risk factors for this outcome were established (being female, consolidation phase of treatment, and previous kinetosis), and evidence suggested that the Eberhart score was not suitable for the studied population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14756","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T07:23:35Z","timestamp":1695194615000},"page":"51-59","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vomiting after intrathecal chemotherapy under anesthesia in pediatric patients with hematologic cancers: A cohort study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3460-7612","authenticated-orcid":false,"given":"Gustavo Henrique","family":"Fran\u00e7a\u00a0de\u00a0Moraes","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Instituto de Medicina Integral Prof. Fernando Figueira  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5592-1833","authenticated-orcid":false,"given":"Luciana Cavalcanti","family":"Lima","sequence":"additional","affiliation":[{"name":"Department of Pediatric Anesthesiology Instituto de Medicina Integral Prof. Fernando Figueira  Recife Brazil"},{"name":"Faculdade Pernambucana de Sa\u00fade  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania Cursino de Menezes","family":"Couceiro","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Instituto de Medicina Integral Prof. Fernando Figueira  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9155-5030","authenticated-orcid":false,"given":"Mecneide Mendes","family":"Lins","sequence":"additional","affiliation":[{"name":"Pediatric Oncology Unit Instituto de Medicina Integral Prof. Fernando Figueira  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6222-1074","authenticated-orcid":false,"given":"D\u00e9bora de Oliveira","family":"Cumino","sequence":"additional","affiliation":[{"name":"Department of Pediatric Anesthesiology Hospital Infantil Sabar\u00e1  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6446-1947","authenticated-orcid":false,"given":"Leonardo Augusto Barbosa Magalh\u00e3es","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Faculdade Pernambucana de Sa\u00fade  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4645-8343","authenticated-orcid":false,"given":"Maria J\u00falia Gon\u00e7alves de","family":"Mello","sequence":"additional","affiliation":[{"name":"Post Graduate and Research Department Instituto de Medicina Integral Prof. Fernando Figueira  Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30186-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.6987"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0651-1"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2015.12.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000073"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004833"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000135639.57715.6C"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23114"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005200050147"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200112000-00005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.9.1221"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-009-0797-x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24508"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91639-0"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1197\/j.aem.2005.04.019"},{"key":"e_1_2_9_19_1","unstructured":"American Society of Anesthesiologists.Physical Status Classification System \u2013 American Society of Anesthesiologists. 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