{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:51:15Z","timestamp":1747187475499,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,5]],"date-time":"2023-11-05T00:00:00Z","timestamp":1699142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During scoliosis surgery, motor evoked potentials (MEP), and somatosensory evoked potentials (SSEP) have been reported to be affected by the use of higher doses of anesthetic agents. Dexmedetomidine, a sympatholytic agent, an alpha\u20102 receptor agonist, has been used as an adjunctive agent to lower anesthetic dose. However, there is conflicting evidence regarding the effects of dexmedetomidine on the intraoperative neurophysiological monitoring of MEP and SSEP during surgery, particularly among pediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This systematic review aimed to determine whether, during spinal fusion surgery in pediatric patients with scoliosis, dexmedetomidine alters MEP amplitude or SSEP latency and amplitude and, if so, whether different doses of dexmedetomidine display different effects (PROSPERO registration number CRD42022300562).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched PubMed, Scopus, and Cochrane Library on January 1, 2022 and included randomized controlled trials, observational cohort and case\u2013control studies and case series investigating dexmedetomidine in the population of interest and comparing against a standardized anesthesia regimen without dexmedetomidine or comparing multiple doses of dexmedetomidine. Animal and in\u00a0vitro studies and conference abstracts were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found substantial heterogeneity in the risk of bias (per Cochrane\u2010preferred tools) of the included articles (<jats:italic>n<\/jats:italic>\u2009=\u20095); results are summarized without meta\u2010analysis. Articles with the lowest risk of bias indicated that dexmedetomidine was associated with MEP loss and that higher doses of dexmedetomidine increased risk. In contrast, articles reporting no association between dexmedetomidine and MEP loss suffered from higher risk of bias, including suspected or confirmed problems with confounding, outcome measurement, participant selection, results reporting, and lack of statistical transparency and power.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the limitations of the studies available in the literature, it would be advisable to conduct rigorous randomized controlled trials with larger sample sizes to assess the effects of dexmedetomidine use of in scoliosis surgery in pediatric patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14795","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T07:55:16Z","timestamp":1699257316000},"page":"112-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effects of dexmedetomidine on intraoperative neurophysiologic monitoring modalities during corrective scoliosis surgery in pediatric patients: A systematic review"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0473-9764","authenticated-orcid":false,"given":"Ahmed","family":"Abdelaal\u00a0Ahmed\u00a0Mahmoud\u00a0Metwally\u00a0Alkhatip","sequence":"first","affiliation":[{"name":"Department of Anaesthesia Birmingham Children's Hospital  Birmingham UK"},{"name":"Department of Anaesthesia, Faculty of Medicine Beni Suef University  Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerry Elizabeth","family":"Mills","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology University of Canberra  Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Hogue","sequence":"additional","affiliation":[{"name":"Department of Quantitative Health Sciences Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amr","family":"Sallam","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Tallaght University Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Khaled","family":"Hamza","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ehab","family":"Farag","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Faculty of Medicine Beni Suef University  Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6083-5697","authenticated-orcid":false,"given":"Hany\u00a0Mahmoud","family":"Yassin","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Faculty of Medicine Fayoum University  Fayoum Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Wagih","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed Mohamed\u00a0Ibrahim","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Addenbrooke Hospital Cambridge University Hospitals  Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Hussein","family":"Helmy","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Elayashy","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11832-012-0457-4"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000132"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.9.FOCUS12235"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200309000-00029"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.33962\/roneuro-2020-080"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00074"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181e33429"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12630-020-01758-6"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2008.02733.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181d74f55"},{"key":"e_1_2_12_13_1","unstructured":"AlkhatipAAAMM Canchi\u2010MuraliN SallamA et\u00a0al.The Effects of Dexmedetomidine on Intraoperative Neurophysiologic Monitoring Modalities during Corrective Scoliosis Surgery in Pediatric Patients: a Systematic Review and Meta\u2010Analysis. NIHR.2022Available at:https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=300562. Accessed November 1 2022"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_12_15_1","article-title":"Review of the development of the risk of bias tool for nonrandomised studies for interventions\u2013ROBINS\u2010I","author":"Sterne J","year":"2017","journal-title":"Cochrane Scientific Committee"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e318163cca6"},{"key":"e_1_2_12_17_1","first-page":"27","article-title":"Esmolol versus dexmedetomidine in scoliosis surgery: study on intraoperative blood loss and hemodynamic changes","volume":"22","author":"Ibraheim OA","year":"2013","journal-title":"Middle East J Anaesthesiol"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/1053-0770(93)90117-4"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.11952"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101663"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12307"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.9797"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13084"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.09.121"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1953-19.2019"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.01.036"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-016-0217-y"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-023-01990-9"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-018-2520-7"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000003433"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.14795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T04:14:31Z","timestamp":1705551271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.14795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,5]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/pan.14795"],"URL":"https:\/\/doi.org\/10.1111\/pan.14795","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"type":"print","value":"1155-5645"},{"type":"electronic","value":"1460-9592"}],"subject":[],"published":{"date-parts":[[2023,11,5]]},"assertion":[{"value":"2023-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}