{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T18:23:47Z","timestamp":1783103027357,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T00:00:00Z","timestamp":1706140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Junctional ectopic tachycardia (JET) is a serious tachyarrhythmia following pediatric cardiac surgery. It isn't easy to treat and better to be prevented. This study aimed to examine the prophylactic effects of dexmedetomidine, MgSO<jats:sub>4<\/jats:sub>, or their combination in reducing JET following pediatric open cardiac surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hundred and twenty children under 5\u2009years, weighing more than 5\u2009kg, who were scheduled for corrective acyanotic cardiac surgeries were randomized into three groups. Group MD (Dexmedetomidine\u2013MgSO<jats:sub>4<\/jats:sub> group): received dexmedetomidine 0.5\u2009\u03bcg\/kg IV over 20\u2009min after induction, then infusion 0.5\u2009\u03bcg\/kg\/h for 72\u2009h, and 50\u2009mg\/kg bolus of MgSO<jats:sub>4<\/jats:sub> with aortic cross\u2010clamp release, then continued administration for 72\u2009h postoperatively at a dose of 30\u2009mg\/kg\/day. Group D (the dexmedetomidine group) received the same dexmedetomidine as the MD group in addition to normal saline instead of MgSO<jats:sub>4<\/jats:sub>. Group C (control group): received normal saline instead of dexmedetomidine and MgSO<jats:sub>4<\/jats:sub>. The primary outcome was the detection of JET incidence; the secondary outcomes were hemodynamic parameters, ionized Mg, vasoactive\u2010inotropic score, extubation time, PCCU and hospital stay, and perioperative complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of JET was significantly reduced in Group MD and Group D (<jats:italic>p<\/jats:italic>\u2009=\u2009.007) compared to Group C. Ionized Mg was significantly higher in Group MD than in Groups D and C during rewarming and in the ICU (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Better hemodynamic profile in Group MD compared to Group D and Group C throughout surgery and in the ICU, the predictive indexes were significantly better in Group MD than in Groups D and C (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Including the extubation time, PCCU, and hospital stay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dexmedetomidine alone or combined with MgSO<jats:sub>4<\/jats:sub> had a therapeutic role in the prevention of JET in children after congenital heart surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.14848","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T09:04:47Z","timestamp":1706173487000},"page":"459-466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dexmedetomidine and magnesium sulfate in preventing junctional ectopic tachycardia after pediatric cardiac surgery"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-4187","authenticated-orcid":false,"given":"Passaint Fahim","family":"Hassan","sequence":"first","affiliation":[{"name":"Intensive Care, and Pain Management, Kasr Al Aini Hospital Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3594-4103","authenticated-orcid":false,"given":"Ahmed M.","family":"El\u00a0Haddad","sequence":"additional","affiliation":[{"name":"Intensive Care, and Pain Management, Kasr Al Aini Hospital Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.04.002"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2011.04.099"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00040-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(02)04014-6"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199711000-00033"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/83.2.302"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5223(00)70083-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-9784.191564"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-017-2969-x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13405"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2009.07.064"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(01)01089-2"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-016-1343-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135118813124"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-022-02916-w"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2017.04.010"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.114.002301"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/2150135119842873"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199107000-00018"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.05306.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1749-8090-5-85"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-013-0658-8"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.14848","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T07:24:15Z","timestamp":1714116255000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.14848"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,25]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/pan.14848"],"URL":"https:\/\/doi.org\/10.1111\/pan.14848","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,25]]},"assertion":[{"value":"2023-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}