{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T16:10:11Z","timestamp":1776269411678,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Remimazolam is a novel ultrashort\u2010acting benzodiazepine, which like midazolam, results in sedation, anxiolysis, and amnesia through its agonistic effects on the gamma\u2010amino butyric acid A receptor. As opposed to midazolam, its unique metabolism is via tissue esterases, which results in a rapid elimination with a limited context sensitive half\u2010life and prompt dissipation of its effect when administration is discontinued. Remimazolam received <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content> approval for use in adults in 2020. In preliminary and initial clinical trials, its efficacy and safety has been suggested in the adult population, both as a primary agent for procedural sedation or as an adjunct to general anesthesia. There are limited data regarding the use of remimazolam in infants and children and its use in this population remains off label as it does not hold <jats:styled-content style=\"fixed-case\">FDA<\/jats:styled-content>\u2010approval in pediatric\u2010aged patients. This narrative outlines the pharmacologic properties of this unique medication, reviews previous published reports of its role in pediatric\u2010aged patients, and discusses dosing parameters and clinical use in this population.<\/jats:p>","DOI":"10.1111\/pan.14970","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T11:05:17Z","timestamp":1721214317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical experience with remimazolam in pediatric anesthesiology: An educational focused review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0550-6951","authenticated-orcid":false,"given":"Joseph D.","family":"Tobias","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Anesthesiology and Pain Medicine The Ohio State University College of Medicine  Columbus Ohio USA"},{"name":"Department of Pediatrics The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-021-01544-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.17085\/apm.21115"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/TCRM.S304556","article-title":"Efficacy and safety profile of remimazolam for sedation in adults undergoing short surgical procedures","volume":"18","author":"Morimoto Y","year":"2022","journal-title":"Ther Clin Risk Manag"},{"issue":"4","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.23736\/S0375-9393.21.15917-6","article-title":"Gastroscopy sedation: clinical trial comparing propofol and sufentanil with or without remimazolam","volume":"88","author":"Xiao 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