{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:06:09Z","timestamp":1787241969803,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Procedural sedation and analgesia are required for painful hemato\u2010oncological procedures such as lumbar and bone marrow punctures. At our institution, sedation with propofol and alfentanil is usually provided by Physician Assistants in Anesthesia. We evaluated the adverse events during the PSA program for children, provided by Physician Assistants in Anesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and Methods<\/jats:title>\n                    <jats:p>We included pediatric patients meeting our criteria for deep sedation by a Physician Assistants in Anesthesia, scheduled for a hemato\u2010oncological procedure at the Amalia Children's Hospital at the Radboudumc Nijmegen. The primary outcome was oxygen desaturation below 92% for more than 20\u2009s. We prospectively collected data on demographics, current health problems, type of procedure, need for airway interventions, and hypotension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We collected data from 437 sedation sessions involving 71 patients. No oxygen desaturation below 92% lasting longer than 20\u2009s occurred. In 2 cases, a jaw thrust was performed. No invasive airway techniques (oropharyngeal cannula, laryngeal mask, or intubation) were required. A significant drop in mean arterial pressure was seen in 2 out of 437 cases (0.5%). There was no occurrence of cardiopulmonary resuscitation or other adverse events such as aspiration or laryngeal spasm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Sedation and analgesia for short painful procedures in selected pediatric hemato\u2010oncological units with a dedicated protocol may be safely provided by trained and certified Physician Assistants in Anesthesia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pan.15014","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T11:48:16Z","timestamp":1727956096000},"page":"33-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of propofol\u2010based procedural sedation in pediatric hemato\u2010oncological patients provided by physician assistants in anesthesia"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3192-4123","authenticated-orcid":false,"given":"I.","family":"van Langeveld","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Pain, and Palliative Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Aalbers","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain, and Palliative Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Prudon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain, and Palliative Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Koning","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Dors","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Hampsink","sequence":"additional","affiliation":[{"name":"Department of Pediatric Oncology Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0953-8053","authenticated-orcid":false,"given":"E. M.","family":"Bronkhorst","sequence":"additional","affiliation":[{"name":"Department for Health Evidence Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. J.","family":"Scheffer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain, and Palliative Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2739-8667","authenticated-orcid":false,"given":"I.","family":"Malagon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain, and Palliative Medicine Radboud University Medical Center  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3686-2481","authenticated-orcid":false,"given":"M.","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain, and Palliative Medicine Radboud University Medical Center  Nijmegen The Netherlands"},{"name":"Department of Anesthesiology, Wilhelmina Children's Hospital University Medical Centre Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(96)71564-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/jsh022"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.152.2.147"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e31818fc334"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/XAA.0000000000000339"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.7861\/fhj.2022-0033"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001310"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2004.01279.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200509000-00009"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2010.03398.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9592.1999.00364.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2478\/s11536-008-0001-6"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.15014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T03:46:52Z","timestamp":1733716012000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.15014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/pan.15014"],"URL":"https:\/\/doi.org\/10.1111\/pan.15014","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]},"assertion":[{"value":"2023-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}