{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:41:21Z","timestamp":1777920081078,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Congenital cardiac surgery with cardiopulmonary bypass (CPB) alters patients' hemostasis. Viscoelastic testing is a modern technology identifying coagulation abnormalities. A new device, the Quantra\u2010QPlus System (HemoSonics LLC, Charlottesville, VA) has not yet been investigated during congenital cardiac surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This prospective observational pilot study investigated the correlation of Quantra and TEG\u20105000 in children undergoing cardiac surgery at Stanford Medicine Children's Health (SMCH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (0\u20138\u2009years) undergoing cardiac surgery with CPB were included after parental consent. Per standard of care at SMCH, a TEG\u20105000 and Clauss Fibrinogen were measured on CPB during rewarming (T1) as well as after administration of blood components and coagulation factors (T2). For the study purpose, Quantra measurements were performed simultaneously at T1 and T2. Quantra results were correlated with TEG\u20105000 results and Clauss Fibrinogen. In addition, the agreement for normal and abnormal results was calculated, and a post hoc simulated transfusion algorithm using TEG\u20105000 and Quantra thresholds was compared to patients' clinical management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From October 2022 to May 2023, 289 congenital cardiac surgeries were performed, 97 met inclusion criteria, 63 patients were consented, and 40 patients (12 females [30%] 28 males [70%]) included in the analysis. Median age and weight were 0.5\u2009years and 6.33\u2009kg, respectively. Correlation of Quantra\/Clauss Fibrinogen was \u201cmoderate\u201d and correlation of Quantra\/TEG\u20105000 parameters ranged from \u201cweak\u201d to \u201cvery strong\u201d Levels of agreement ranged from 15% to 97%. The post hoc simulated transfusion algorithm for TEG\u20105000 showed an agreement of 56% for FFP, 56% for Fibrinogen, and 95% for platelets and for Quantra, it was 40% for FFP, 87.5% for Fibrinogen, and 98% for platelets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite weaknesses in correlation and agreement both VET devices suggested appropriate coagulation management based on the simulated transfusion algorithms. Quantra and TEG\u20105000 are not interchangeable and none of them can be considered as \u201cthe gold standard\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>NTC 05295693<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.15097","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T12:23:04Z","timestamp":1742214184000},"page":"469-480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the Point\u2010Of\u2010Care Coagulation Device Quantra With the <scp>TEG<\/scp>\u20105000 for Congenital Cardiac Surgery\u2014A Pilot Study"],"prefix":"10.1111","volume":"35","author":[{"given":"Dominik","family":"Ochocinski","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University\u2014School of Medicine  Stanford California USA"},{"name":"Department of Anesthesia and Perioperative Care University of California San Francisco  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manchula","family":"Navaratnam","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University\u2014School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Babb","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University\u2014School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"De Souza","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University\u2014School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Komal","family":"Kamra","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University\u2014School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin R.","family":"Sleasman","sequence":"additional","affiliation":[{"name":"Perfusion, Perioperative Services Stanford Medicine Children's Health  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tristan Day","family":"Margetson","sequence":"additional","affiliation":[{"name":"Perfusion, Perioperative Services Stanford Medicine Children's Health  Palo Alto California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti K.","family":"Bhamidipati","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University\u2014School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chandra","family":"Ramamoorthy","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University\u2014School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4114-6957","authenticated-orcid":false,"given":"Alexander R.","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Perioperative and Pain Medicine Stanford University\u2014School of Medicine  Stanford California USA"},{"name":"Department of Anesthesia and Children's Research Centre University Children's Hospital  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c84ba5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.9.1680.1680"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2013.05.014"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.03.015"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev369"},{"issue":"6","key":"e_1_2_11_7_1","first-page":"S75","article-title":"Viscoelastic Testing in Pediatric Patients","volume":"60","author":"Haas T.","year":"2020","journal-title":"Transfusion"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2020.11.008"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.01.011"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2020.11.058"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2023.01.034"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2023.02.015"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.26578"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001362"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14563"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001721-200107000-00001"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23599"},{"key":"e_1_2_11_18_1","unstructured":"Haemoscope Corporation \u201cN Illinois 60714\u20103403 USA. User Manuel\u2014TEG 5000 Thrombelastograph Hemostasis System \u201d2008TEG Analytical Software (TAS) Version 4.2.3."},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-015-1460-y"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3175-1_50"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001413"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26285"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000859"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12191"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30794"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2010.05.144"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2018.07.032"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2020.07.026"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1265289"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2023.09.001"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-3175-1_1"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/86.4.575"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.07.011"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2010.01.003"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e31824d523b"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134811.27812.F0"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001058"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.5.1651.1651"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001509"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-021-01469-5"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X18811731"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318220755c"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2014.05.023"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/jalm\/jfaa057"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.15097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T13:18:37Z","timestamp":1748351917000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.15097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/pan.15097"],"URL":"https:\/\/doi.org\/10.1111\/pan.15097","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,17]]},"assertion":[{"value":"2024-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}