{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:06:18Z","timestamp":1790730378336,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T00:00:00Z","timestamp":1742169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>Children with oropharyngeal cleft deformity (OPCD) undergoing reconstructive surgery are at greater risk for perioperative respiratory adverse events (PRAEs). Predictors for PRAE specific to this population have not been investigated, despite it being the most common congenital malformation seen worldwide.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This single\u2010center, prospective, observational study recruited 270 children under 2\u2009years of age, undergoing elective cleft surgery from May 1, 2023, to June 30, 2024. The primary aim was to identify predictors of pre\u2010determined PRAE (laryngospasm, bronchospasm, stridor, airway obstruction and desaturation). We also aimed to identify the more common PRAE in this patient population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 345 children who underwent cleft correction surgery, 270 were included in the study. There was a statistically increased incidence of PRAE in children with a positive history of upper airway obstruction and a history of feeding disorder in early infancy, Cormack Lehane (CL) grade \u2265\u20093, and COLDS score \u2265\u200915. A significant association was found between the COLDS score (odds ratio [OR]: 0.005, 95% confidence interval [CI]: 0.001\u20130.049), CL grade \u2265\u20093 (OR: 0.008, 95% CI: 0.001\u20130.078) and PRAE.COLDS score \u2265\u200915 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.046; adjusted OR [AOR]: 18.07, 95% CI: 1.06\u2013308.45) and CL grade \u2265\u20093 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007; AOR: 41.79, 95% CI: 2.74\u2013636.40) were associated with PRAEs in the multivariate regression. The overall incidence of PRAE was 1.85%, laryngospasm being the most common.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Children with OPCD with higher COLDS scores and\/or those with a CL grade view \u2265\u20093 are more likely to develop PRAE following corrective surgery. The limited data indicate the increased possibility of PRAE in children with a positive history of airway obstruction and\/or feeding disorder in early infancy. The relatively low incidence of PRAE restricts the generalizability.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/pan.15100","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T08:23:39Z","timestamp":1742199819000},"page":"1024-1028","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictors of Perioperative Respiratory Adverse Events in Children Undergoing Surgery for Oropharyngeal Cleft Deformity: A Prospective Observational Study (PRAE\u2010OPCD Study)"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1325-0940","authenticated-orcid":false,"given":"Usha","family":"Shenoy","sequence":"first","affiliation":[{"name":"Jubilee Mission Medical College &amp; Research Institute  Thrissur Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijoy","family":"Chirayath","sequence":"additional","affiliation":[{"name":"Jubilee Mission Medical College &amp; Research Institute  Thrissur Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. V.","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Jubilee Mission Medical College &amp; Research Institute  Thrissur Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avni","family":"Francis","sequence":"additional","affiliation":[{"name":"Jubilee Mission Medical College &amp; Research Institute  Thrissur Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam Koshy","family":"Thomas","sequence":"additional","affiliation":[{"name":"Jubilee Mission Medical College &amp; Research Institute  Thrissur Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Rajagopal","sequence":"additional","affiliation":[{"name":"Jubilee Mission Medical College &amp; Research Institute  Thrissur Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,17]]},"reference":[{"issue":"7","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.21037\/tp-21-257","article-title":"Identification of the Risk Factors in Perioperative Respiratory Adverse Events in Children Under General Anesthesia and the Development of a Predictive Model","volume":"10","author":"Tao S.","year":"2021","journal-title":"Translational Pediatrics"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjae.2021.06.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000001216"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.827663","article-title":"Perioperative Respiratory Adverse Events Among Pediatric Surgical Patients in University Hospitals in Northwest Ethiopia; A Prospective Observational Study","volume":"10","author":"Wudineh D. M.","year":"2022","journal-title":"Frontiers in Pediatrics"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003430"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.19"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58101340"},{"issue":"10","key":"e_1_2_7_9_1","first-page":"2072","article-title":"Pediatric Anesthesia Adverse Events: The Thai Anesthesia Incidents Study (THAI Study) Database of 25,098 Cases","volume":"90","author":"Bunchungmongkol N.","year":"2007","journal-title":"Journal of the Medical Association of Thailand"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkt031"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5049.123328"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12337"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(15)00508-1"},{"issue":"5","key":"e_1_2_7_14_1","doi-asserted-by":"crossref","DOI":"10.1016\/S2213-2600(17)30116-9","article-title":"Incidence of Severe Critical Events in Paediatric Anaesthesia (APRICOT): A Prospective Multicentre Observational Study in 261 Hospitals in Europe","volume":"5","author":"Habre W.","year":"2017","journal-title":"Lancet Respiratory Medicine"},{"issue":"7","key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.bjoms.2015.06.008","article-title":"Contemporary Management of Cleft Lip and Palate in the UK. Have We Reached the Turning Point? A Commentary","volume":"53","author":"Beale V.","year":"2015","journal-title":"British Journal of Oral & Maxillofacial Surgery"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200008000-00026"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mki021"},{"key":"e_1_2_7_18_1","unstructured":"Anesthesia Patient Safety Foundation \u201cTeamwork in the Operating Room: An Essential for Patient Safety \u201dJanuary 11 2025 https:\/\/www.apsf.org\/article\/teamwork\u2010in\u2010the\u2010operating\u2010room\u2010an\u2010essential\u2010for\u2010patient\u2010safety\/."}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.15100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T09:08:54Z","timestamp":1762852134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.15100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,17]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/pan.15100"],"URL":"https:\/\/doi.org\/10.1111\/pan.15100","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,17]]},"assertion":[{"value":"2024-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}