{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:02:08Z","timestamp":1781812928396,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012285","name":"BC Children's Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024843","name":"Biotalent Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Posterior spinal instrumentation and fusion is a common surgical correction for adolescent idiopathic scoliosis. Preventative multimodal analgesia, including opioids, is required to minimize postoperative pain, but opioids are associated with dose\u2010dependent side effects that may disrupt recovery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We hypothesized that the addition of 48\u2010h perioperative intravenous lidocaine therapy to a multimodal analgesia regimen would reduce morphine utilization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We conducted a double\u2010blinded randomized controlled trial in 10\u201319\u2009years\u2009old, ASA I\u2013III, undergoing single\u2010stage scoliosis correction. Participants were randomly allocated to the Intervention group (intravenous lidocaine 1\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup> bolus at anesthesia start, followed by 2\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u2009h<jats:sup>\u22121<\/jats:sup> infusion for 8\u2009h, followed by 1\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u2009h<jats:sup>\u22121<\/jats:sup> for 40\u2009h) or Control (normal saline). Participants received standardized perioperative multimodal analgesia, including a postoperative morphine infusion with titration rules protocolized to self\u2010reported pain scores. The primary outcome was 48\u2010h morphine utilization; secondary outcomes were median and worst pain scores, and times to first stand, first walk &gt;\u200915 steps, urinary catheter removal, termination of morphine infusion, and hospital discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Data were available from 38 participants: 32 (84%) female; median (IQR) age 16.3 (14.9\u201317.2) years, with curve magnitude (Cobb angle) 62 (56\u201370) degrees. The 48\u2010h morphine utilization did not differ between groups: Intervention median (IQR) 0.86 (0.73\u20131.05) mg\u2009kg<jats:sup>\u22121<\/jats:sup> versus Control 1.00 (0.77\u20131.18) mg\u2009kg<jats:sup>\u22121<\/jats:sup>; median difference \u22120.11 (95% CI \u22120.30 to 0.13) mg\u2009kg<jats:sup>\u22121<\/jats:sup>; <jats:italic>p<\/jats:italic>\u2009=\u20090.264. There were similarly no differences in morphine utilization at 12, 24, or 36\u2009h or any secondary outcome, except the first postoperative pain score: Intervention 3\/10 (1.75\u20135) versus Control 5\/10 (3\u20137); median difference \u22122 (95% CI 0 to \u22123); <jats:italic>p<\/jats:italic>\u2009=\u20090.035. Three cases with mild symptoms of suspected local anesthetic systemic toxicity were observed in the Intervention group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found no evidence to support the adjunctive use of 48\u2010h perioperative intravenous lidocaine therapy in adolescents undergoing scoliosis correction in which effective multimodal analgesia was adopted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>ClinicalTrials.gov identifier: NCT04069169<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.15124","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T12:19:19Z","timestamp":1746533959000},"page":"552-561","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Perioperative Intravenous Lidocaine Infusion Therapy as an Adjunct to Multimodal Analgesia for Adolescent Idiopathic Scoliosis Surgical Correction: A Double\u2010Blind Randomized Controlled Trial"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2953-5305","authenticated-orcid":false,"given":"Jessica","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Anesthesia BC Children's Hospital  Vancouver British Columbia Canada"},{"name":"Research Institute BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-5136","authenticated-orcid":false,"given":"Nicholas","family":"West","sequence":"additional","affiliation":[{"name":"Department of Anesthesia BC Children's Hospital  Vancouver British Columbia Canada"},{"name":"Research Institute BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Anesthesia BC Children's Hospital  Vancouver British Columbia Canada"},{"name":"Research Institute BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanisah","family":"Golam","sequence":"additional","affiliation":[{"name":"Department of Anesthesia BC Children's Hospital  Vancouver British Columbia Canada"},{"name":"Research Institute BC Children's Hospital  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Adams","sequence":"additional","affiliation":[{"name":"Pharmacy BC Children's and Women's Hospital  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2193-178X","authenticated-orcid":false,"given":"Matthias","family":"G\u00f6rges","sequence":"additional","affiliation":[{"name":"Research Institute BC Children's Hospital  Vancouver British Columbia Canada"},{"name":"Department of Anesthesiology, Pharmacology, &amp; Therapeutics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxane R.","family":"Carr","sequence":"additional","affiliation":[{"name":"Research Institute BC Children's Hospital  Vancouver British Columbia Canada"},{"name":"Pharmacy BC Children's and Women's Hospital  Vancouver British Columbia Canada"},{"name":"Faculty of Pharmaceutical Sciences University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firoz","family":"Miyanji","sequence":"additional","affiliation":[{"name":"Research Institute BC Children's Hospital  Vancouver British Columbia Canada"},{"name":"Department of Orthopaedics BC Children's Hospital  Vancouver British Columbia Canada"},{"name":"Department of Orthopaedics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gillian R.","family":"Lauder","sequence":"additional","affiliation":[{"name":"Department of Anesthesia BC Children's Hospital  Vancouver British Columbia Canada"},{"name":"Research Institute BC Children's Hospital  Vancouver British Columbia Canada"},{"name":"Department of Anesthesiology, Pharmacology, &amp; Therapeutics University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.1025"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40272-020-00423-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2192568219858308"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/2152-7806.130674"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000002189"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14608"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.5772\/66771"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2013.09.031"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318297d4a5"},{"issue":"6","key":"e_1_2_10_11_1","article-title":"Continuous Intravenous Perioperative Lidocaine Infusion for Postoperative Pain and Recovery in Adults","volume":"6","author":"Weibel S.","year":"2018","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2021.03.024"},{"key":"e_1_2_10_13_1","unstructured":"A.Umedaly N.Lowlaavar N.West F.Miyanji andG. R.Lauder \u201cEvaluation of Intra\u2010Operative Intravenouse Lidocaine Administration During Idiopathic Scoliosis Correction in Children; A Retrospective Case\u2010Matched Analysis \u201dinInternational Symposium on Pediatric Pain Seattle WA(2015)."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04337-3"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2017.09.009"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14895"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000001370"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-021-01281-1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex038"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.15015"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-020-00100-7"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/pan.15019"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43390-023-00753-3"}],"container-title":["Pediatric Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pan.15124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T05:05:08Z","timestamp":1749531908000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pan.15124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,6]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/pan.15124"],"URL":"https:\/\/doi.org\/10.1111\/pan.15124","archive":["Portico"],"relation":{},"ISSN":["1155-5645","1460-9592"],"issn-type":[{"value":"1155-5645","type":"print"},{"value":"1460-9592","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,6]]},"assertion":[{"value":"2025-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}