{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:39:29Z","timestamp":1778503169690,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pediatric Anesthesia"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Endotracheal tube (ETT) cuff pressures that exceed 20\u201330 cmH<jats:sub>2<\/jats:sub>O may lead to iatrogenic adverse effects such as cough, sore throat, and tracheal edema or more serious complications including tracheal stenosis, recurrent laryngeal nerve injury, and tracheal rupture. The current study evaluates a novel technique, titration of the ratio of expiratory to inspiratory tidal volumes (TV), to regulate intracuff pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective, cross\u2010over trial measured intracuff pressure in a cohort of pediatric patients presenting for general anesthesia with an ETT. Intracuff pressure was measured following adjustment of the expiratory to inspiratory TV to various ratios (1.0, 0.9, and 0.8) by slow removal of air from the ETT cuff.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort included 50 patients with a median age of 12\u2009years. At baseline continuous positive airway pressure (CPAP), the median (IQR) intracuff pressure was 20.4 cmH<jats:sub>2<\/jats:sub>O (13.6, 28.8). The intracuff pressure decreased to 12.2 cmH<jats:sub>2<\/jats:sub>O (10.2, 18.4) at an expired tidal volume (TV<jats:sub>e<\/jats:sub>) to inspired tidal volume (TV<jats:sub>i<\/jats:sub>) ratio of 1, 8.9 cmH<jats:sub>2<\/jats:sub>O (7.4, 10.9) at 0.9, and to 8.2 cmH<jats:sub>2<\/jats:sub>O (6.8, 9.5) at a ratio of 0.8. With both the CPAP method and TVe\/TVi ratio of 1, there were cuff pressures greater than 30 cmH<jats:sub>2<\/jats:sub>O (10 with CPAP and 2 with TVe\/TVi ratio of 1). With a TVe\/TVi ratio of 0.9 or 0.8, there were no cuff pressures greater than 30 cmH<jats:sub>2<\/jats:sub>O.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adjustment of the TVe\/TVi may be a more effective means of ensuring that the cuff pressure is in the desired range than other conventionally used clinical techniques such as sealing the airway to a CPAP of 20 cmH<jats:sub>2<\/jats:sub>O.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial Registration<\/jats:title><jats:p>ClinicalTrials.gov: NCT02768831<\/jats:p><\/jats:sec>","DOI":"10.1111\/pan.70045","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T06:50:16Z","timestamp":1757141416000},"page":"940-945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Regulation of Intracuff Pressure by Measurement of the Ratio of Expiratory to Inspiratory Tidal Volumes"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2364-3941","authenticated-orcid":false,"given":"Kelly","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibelle Aurelie Yemele","family":"Kitio","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Rice\u2010Weimer","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children's Hospital  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0550-6951","authenticated-orcid":false,"given":"Joseph D.","family":"Tobias","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pain Medicine Nationwide Children's Hospital  Columbus Ohio USA"},{"name":"Department of Anesthesiology &amp; Pain Medicine The Ohio State University College of Medicine  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-007-0931-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2015-309240"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2021.02.064"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2010.02261.x"},{"issue":"1","key":"e_1_2_10_6_1","article-title":"Cuffed Versus Uncuffed Endotracheal Tubes for Neonates","volume":"1","author":"Dariya V.","year":"2022","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0b013e3181e89834"},{"issue":"10","key":"e_1_2_10_8_1","first-page":"1631","article-title":"Effect of Endotracheal Tube Leak on Capnographic Measurements in a Ventilated Neonatal Lung Mode","volume":"33","author":"Schmalisch G.","year":"2012","journal-title":"Physics in Medicine and Biology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199703000-00015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.288.6422.965"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/175045891102101103"},{"key":"e_1_2_10_12_1","first-page":"1","article-title":"Measuring Endotracheal Tube Intracuff Pressure: No Room for Complacency","volume":"35","author":"Kumar C. 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