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Although <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content> pathophysiology is still not fully understood, a number of neuroendocrine, neurotransmission and neurosensitive disorders might generate a mechanism for the elicitation of pain by \u201ccentral sensitization,\u201d which is common to many other painful conditions. The present case describes the success of a therapeutic scheme, which associates two different pharmacological classes, anticonvulsants and new\u2010generation antidepressants, when <jats:styled-content style=\"fixed-case\">FMS<\/jats:styled-content> complicates a rare pathology called Cogan's syndrome. The association of two drugs might noticeably affect the molecular mechanisms of difficult pain, thus solving painful conditions of multifactorial origin.<\/jats:p>","DOI":"10.1111\/papr.12009","type":"journal-article","created":{"date-parts":[[2012,11,6]],"date-time":"2012-11-06T03:51:08Z","timestamp":1352173868000},"page":"657-662","source":"Crossref","is-referenced-by-count":7,"title":["Duloxetine and Pregabalin for Pain Management in Multiple Rheumatic Diseases Associated with Fibromyalgia"],"prefix":"10.1111","volume":"13","author":[{"given":"Chiara","family":"Angeletti","sequence":"first","affiliation":[{"name":"Anesthesiology and Pain Medicine Department of Health Sciences University of L'Aquila Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana","family":"Guetti","sequence":"additional","affiliation":[{"name":"Anesthesiology and Pain Medicine Department of Health Sciences University of L'Aquila 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