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There is paucity of literature on interlaminar epidural injections in managing lumbar disc herniation or radiculitis in contemporary interventional pain management settings utilizing fluoroscopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A randomized, double\u2010blind, active\u2010control trial was undertaken to assess the effectiveness of lumbar interlaminar epidural injections with or without steroids for disc herniation and radiculitis. The primary outcome was defined as pain relief and functional status improvement of \u2265\u00a050%. One hundred twenty patients were randomly assigned to 1 of the 2 groups. Group <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> patients received lumbar interlaminar injections containing a local anesthetic (lidocaine 0.5%, 6\u00a0mL), whereas Group <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> patients received lumbar interlaminar epidural injections of 0.5% lidocaine, 5\u00a0mL, mixed with 1\u00a0mL of non\u2010particulate betamethasone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the patients who responded with initial 2 procedures with at least 3\u00a0weeks of relief, significant improvement was seen in 80% of the patients in the local anesthetic group and 86% of the patients in the local anesthetic and steroid group. The overall average procedures per year were 3.6 in the local anesthetic group and 4.1 in the local anesthetic and steroid group, with an average relief of 33.7\u00a0\u00b1\u00a018.1\u00a0weeks in the local anesthetic group and 39.1\u00a0\u00b1\u00a012.2\u00a0weeks in the local anesthetic and steroid group over a period of 52\u00a0weeks in the overall population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lumbar interlaminar epidural injections of local anesthetic with or without steroids might be effective in patients with disc herniation or radiculitis, with potential superiority of steroids compared with local anesthetic alone at 1\u00a0year follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12023","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T11:32:19Z","timestamp":1356607939000},"page":"547-558","source":"Crossref","is-referenced-by-count":28,"title":["The Role of Fluoroscopic Interlaminar Epidural Injections in Managing Chronic Pain of Lumbar Disc Herniation or Radiculitis: A Randomized, Double\u2010Blind Trial"],"prefix":"10.1111","volume":"13","author":[{"given":"Laxmaiah","family":"Manchikanti","sequence":"first","affiliation":[{"name":"Pain Management Center of Paducah Paducah Kentucky U.S.A"},{"name":"University of Louisville Louisville Kentucky U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay","family":"Singh","sequence":"additional","affiliation":[{"name":"Spine Pain Diagnostics Associates Niagara Wisconsin U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly A.","family":"Cash","sequence":"additional","affiliation":[{"name":"Pain Management Center of Paducah Paducah Kentucky U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vidyasagar","family":"Pampati","sequence":"additional","affiliation":[{"name":"Pain Management Center of Paducah Paducah Kentucky U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J. 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