{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T10:36:21Z","timestamp":1764239781378},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T00:00:00Z","timestamp":1372032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our goal was to ascertain the prevalence of widespread pain in our cohort of patients with complex regional pain syndrome (<jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of clinical letters and notes. We assessed data from consecutive patients diagnosed with <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> according to the <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>udapest criteria, after a referral to one consultant at a tertiary <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ain <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edicine referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 2007 and <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>eptember 2012, 190 patients (149 females) received a diagnosis of <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> according to the Budapest criteria, and an additional 26 patients received the diagnosis of <jats:styled-content style=\"fixed-case\">CRPS NOS<\/jats:styled-content> (not otherwise specified). The <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> patients were an average of 44\u00a0years of age, and had a median disease duration of 18\u00a0months. Before the <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> incident trigger, a third had already experienced other than everyday pains in the now <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content>\u2010affected limb. Twenty\u2010one patients (11.1%) experienced widespread pain in clinic, which was often not communicated in the referral letters. The types of triggering traumata and frequencies of Budapest signs and symptoms did not differ between patients with or without widespread pain. All patients considered their widespread pain as an important factor affecting their quality of life; for the majority it was of similar severity to the <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content> pain. Additional patients reported <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content>\u2010concomitant regional pains, most commonly headaches\/migraines, lower back pain, and irritable bowel syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In this systematic assessment of the incidence of widespread pain in a large cohort of patients with <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content>, important widespread pain affected &gt;\u00a010% of patients. Our data support the inclusion of routine enquiries about additional pains in the clinical assessment of patients with <jats:styled-content style=\"fixed-case\">CRPS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12092","type":"journal-article","created":{"date-parts":[[2013,6,24]],"date-time":"2013-06-24T09:22:50Z","timestamp":1372065770000},"page":"526-531","source":"Crossref","is-referenced-by-count":15,"title":["Widespread Pain in Patients with Complex Regional Pain Syndrome"],"prefix":"10.1111","volume":"14","author":[{"given":"Thomas","family":"Birley","sequence":"first","affiliation":[{"name":"University Hospital Aintree Liverpool U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Goebel","sequence":"additional","affiliation":[{"name":"Walton Centre NHS Foundation Trust Liverpool U.K"},{"name":"University of Liverpool University Liverpool U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker202"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000028686.74056.E3"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.07.002"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09638280500287320"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.psy.44.2.173"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92877-V"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00246-2"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31818ecea5"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0404.2000.101004262x.\/"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.02.013"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(01)00332-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.11-6-596"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.216"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2011.00064.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.04.030"},{"key":"e_1_2_5_17_1","first-page":"212","volume-title":"Classification of Chronic Pain","author":"Merskey H","year":"1994"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00332-8"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(95)00160-3"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.20140"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e3181a11623"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.09.008"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12092","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T16:32:52Z","timestamp":1695573172000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,24]]},"references-count":21,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["10.1111\/papr.12092"],"URL":"https:\/\/doi.org\/10.1111\/papr.12092","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,24]]}}}