{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:11:39Z","timestamp":1695618699114},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Carpal tunnel syndrome (<jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>) is a common entrapment neuropathy of the median nerve at the wrist that is characterized by pain, paresthesias, weakness, and loss of dexterity. This pilot study was conducted to evaluate the heated lidocaine\/tetracaine patch (<jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content> patch) as a conservative treatment for pain of <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty adult patients (mean age = 44 \u00b1\u00a012\u00a0years) with pain secondary to unilateral <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content> and electrodiagnostic evidence of mild\u2010to\u2010moderate <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content> enrolled in this open\u2010label study. Patients were treated with a single <jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content> patch placed over the junction of forearm and wrist on the palmar aspect of the wrist twice daily (morning and evening at 12\u2010hour intervals) for 2\u00a0hours. At baseline and during the 2\u2010week study, patients graded their pain intensity with an 11\u2010point numerical rating scale (0\u00a0=\u00a0no pain, 10\u00a0=\u00a0worst imaginable pain). Pain interference with general activity, work, and sleep was evaluated with a similar 0\u2010to\u201010\u2010point scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen patients completed the 14\u2010day treatment period. Mean average pain intensity score decreased from 5.1\u00a0\u00b1\u00a01.5 at baseline to 2.5\u00a0\u00b1\u00a01.6 at end of study in the per\u2010protocol population (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Two\u2010thirds of the patients demonstrated clinically meaningful pain relief (\u2265\u00a030% reduction in average pain score), with 40% of the patients reaching this threshold by the third treatment day. Similar improvements were observed for pain interference scores. The <jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content> patch was generally well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">HLT<\/jats:styled-content> patch resulted in clinically meaningful reduction in pain intensity in the majority of patients with mild\u2010to\u2010moderate <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content> and may represent a targeted nonsurgical treatment for pain associated with <jats:styled-content style=\"fixed-case\">CTS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12105","type":"journal-article","created":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T10:34:00Z","timestamp":1375353240000},"page":"607-612","source":"Crossref","is-referenced-by-count":2,"title":["An Open\u2010Label Pilot Study Evaluating the Effectiveness of the Heated Lidocaine\/Tetracaine Patch for the Treatment of Pain Associated with Carpal Tunnel Syndrome"],"prefix":"10.1111","volume":"14","author":[{"given":"Srinivas","family":"Nalamachu","sequence":"first","affiliation":[{"name":"International Clinical Research Institute, Inc. 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