{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:16:19Z","timestamp":1778519779905,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004312","name":"Eli Lilly and Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the efficacy of duloxetine vs. pregabalin in the treatment for diabetic peripheral neuropathic pain (<jats:styled-content style=\"fixed-case\">DPNP<\/jats:styled-content>), comparing patient subgroups with and without concomitant antidepressant use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This post hoc analysis assessed data from a randomized 12\u2010week study that confirmed the noninferiority of duloxetine to pregabalin. In the previously published study, patients with <jats:styled-content style=\"fixed-case\">DPNP<\/jats:styled-content> with inadequate response to gabapentin were switched to duloxetine monotherapy, combination therapy of duloxetine plus gabapentin, or pregabalin monotherapy. Current, stable antidepressant use was allowed; 79 patients were concomitantly treated with antidepressants and 328 without antidepressants. In this post hoc analysis, improvement in the weekly mean of diary\u2010based average daily pain ratings (numerical rating scale: 0\u201310) in antidepressant users and nonusers was analyzed using a longitudinal mixed\u2010models repeated\u2010measures (<jats:styled-content style=\"fixed-case\">MMRM<\/jats:styled-content>) analysis, including a test of the 3\u2010way interaction (antidepressant subgroup by treatment by week) to assess whether the differences among treatment groups over 12\u00a0weeks differ between the antidepressant\u2010use subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 3\u2010way interaction was significant (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.035), demonstrating that treatment\u2010group differences in pain reduction over time differ between the subgroups. Among patients without antidepressant use, patients treated with duloxetine had significantly greater pain reduction than pregabalin at Week 4 and at each successive week up to the 12\u2010week endpoint (\u22122.8 for duloxetine and \u22122.1 for pregabalin; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.031); patients treated with duloxetine plus gabapentin had greater pain reduction than pregabalin at Weeks 2, 3, 5, and 7 to 9 (<jats:italic>P\u00a0<\/jats:italic>\u2264<jats:italic>\u00a0<\/jats:italic>0.05) but not at endpoint (\u22122.4; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.222). Among concomitant antidepressant users, no treatment\u2010group differences were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with <jats:styled-content style=\"fixed-case\">DPNP<\/jats:styled-content> inadequately treated with gabapentin without the concomitant use of antidepressants, switching to duloxetine instead of pregabalin may provide better pain reduction. Conversely, in nonresponders to gabapentin who are concomitantly using an antidepressant, switching to duloxetine or pregabalin may provide similar pain reductions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12121","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T07:16:40Z","timestamp":1382599000000},"page":"640-648","source":"Crossref","is-referenced-by-count":13,"title":["Duloxetine Compared with Pregabalin for Diabetic Peripheral Neuropathic Pain Management in Patients with Suboptimal Pain Response to Gabapentin and Treated with or without Antidepressants: A Post Hoc Analysis"],"prefix":"10.1111","volume":"14","author":[{"given":"Robert J.","family":"Tanenberg","sequence":"first","affiliation":[{"name":"Division of Endocrinology Brody School of Medicine East Carolina University Greenville North Carolina U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B.","family":"Clemow","sequence":"additional","affiliation":[{"name":"Lilly USA LLC Indianapolis Indiana U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Giaconia","sequence":"additional","affiliation":[{"name":"INC Research Raleigh North Carolina U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard C.","family":"Risser","sequence":"additional","affiliation":[{"name":"Lilly Research Laboratories Eli Lilly and Company Indianapolis Indiana U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0649"},{"key":"e_1_2_5_3_1","first-page":"447","volume-title":"Goodman and Gilman's The Pharmacological Basis of Therapeutics","author":"Baldessarini RJ","year":"2001"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2009.0645"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clpt.2003.09.019"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00301-0"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.08.033"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2010.07.014"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(03)90011-7"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0681"},{"key":"e_1_2_5_11_1","first-page":"129","article-title":"Pain assessment: global use of the Brief Pain Inventory","volume":"23","author":"Cleeland CS","year":"1994","journal-title":"Ann Acad Med Singapore"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/11536200-000000000-00000"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.1993.4"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200822050-00005"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2008.00423.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/089198878800100103"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(76)90115-3"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.10.2378"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2010.507192"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.02.021"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12121","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:26:05Z","timestamp":1695561965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,24]]},"references-count":19,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1111\/papr.12121"],"URL":"https:\/\/doi.org\/10.1111\/papr.12121","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,24]]}}}