{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:57:37Z","timestamp":1792213057171,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,14]],"date-time":"2014-02-14T00:00:00Z","timestamp":1392336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The objective of this study was to determine the long\u2010term efficacy of percutaneous glycerol rhizolysis of the trigeminal ganglion for treating patients with trigeminal neuralgia and search for predictors associated with (long\u2010term) benefit to improve patient selection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study in 60 consecutive patients treated with percutaneous glycerol rhizolysis of the trigeminal ganglion for trigeminal neuralgia. Charts were reviewed in combination with follow\u2010up by questionnaire (<jats:italic>n<\/jats:italic>\u00a0=\u00a055, 92% response).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Initial pain relief was achieved in 92% of the patients. Pain\u2010free survival was 59% of the patients at 12\u00a0months and 53% at 24\u00a0months. Most common side effects were hypesthesia (15%), dry eye (5%), and meningitis (2%). In patients without involvement of the third branch of the trigeminal nerve, the initial effect was 79%, of which 90% achieved more than 2\u00a0years pain\u2010free survival, compared with 97% initial effect and less than 40% pain\u2010free survival of more than 2\u00a0years when the third trigeminal branch was involved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The present study demonstrates that involvement of the third branch is a negative predictor for long\u2010term outcome in percutaneous glycerol rhizolysis of the trigeminal ganglion in patients with classical trigeminal neuralgia. However, in the absence of third\u2010branch involvement, glycerol rhizolysis yields excellent long\u2010term results when initial positive effect is obtained.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12175","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T10:05:55Z","timestamp":1392631555000},"page":"217-222","source":"Crossref","is-referenced-by-count":3,"title":["Reduced Effect of Percutaneous Retrogasserian Glycerol Rhizolysis in Trigeminal Neuralgia Affecting the Third Branch"],"prefix":"10.1111","volume":"15","author":[{"given":"Mark V.","family":"Koning","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick J.","family":"Koning","sequence":"additional","affiliation":[{"name":"Departments of Anesthesiology and Cardiothoracic Surgery Institute for Cardiovascular Research VU University Medical Center Amsterdam The Netherlands"},{"name":"Department of Integrated Neurovascular Biology INSERM U1083 CNRS UMR 6214 LUNAM University University of Angers Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henk M.","family":"Koning","sequence":"additional","affiliation":[{"name":"Department of Pain Therapy DC Group Almere The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,2,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000114867.98896.F0"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-007-1488-3"},{"key":"e_1_2_5_4_1","first-page":"CD007312","article-title":"Neurosurgical interventions for the treatment of classical trigeminal neuralgia","author":"Zakrzewska JM","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/02688697.2011.558946"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200411000-00012"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.102.2.0223"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.72.6.0851"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200805000-00006"},{"issue":"1","key":"e_1_2_5_10_1","first-page":"9","article-title":"The International classification of headache disorders: 2nd edition","volume":"24","author":"Headache Classification Subcommittee of the International Headache Society","year":"2004","journal-title":"Cephalalgia"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e31822616d0"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-198112000-00005"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000153907.43563.FF"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318233a85f"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1988.69.1.0039"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.50.11.1536"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-835702"}],"container-title":["Pain Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpapr.12175","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/papr.12175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T21:43:39Z","timestamp":1696283019000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/papr.12175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,14]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/papr.12175"],"URL":"https:\/\/doi.org\/10.1111\/papr.12175","archive":["Portico"],"relation":{},"ISSN":["1530-7085","1533-2500"],"issn-type":[{"value":"1530-7085","type":"print"},{"value":"1533-2500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,14]]}}}