{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:14:07Z","timestamp":1791659647504,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T00:00:00Z","timestamp":1392595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001981","name":"ME Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001981","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Foundation Flanders (FWO)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Practice"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Temporal summation (<jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>) of pain, conditioned pain modulation (<jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content>), and exercise\u2010induced analgesia (<jats:styled-content style=\"fixed-case\">EIA<\/jats:styled-content>) are often investigated in chronic pain populations as an indicator for enhanced pain facilitation and impaired endogenous pain inhibition, respectively, but interactions are not yet clear both in healthy controls and in chronic pain patients. Therefore, the present double\u2010blind randomized placebo\u2010controlled study evaluates pains cores, <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content> in response to exercise in healthy controls, patients with chronic fatigue syndrome and comorbid fibromyalgia (<jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>), and patients with rheumatoid arthritis (<jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>), both under placebo and paracetamol condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifty\u2010three female volunteers \u2013 of which 19 patients with <jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>, 16 patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, and 18 healthy controls \u2013 underwent a submaximal exercise test on a bicycle ergometer on 2 different occasions (paracetamol vs. placebo), with an interval of 7\u00a0days. Before and after exercise, participants rated pain intensity during <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with rheumatoid arthritis showed decreased <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> after exercise, both after paracetamol and placebo (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05). In patients with <jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>, results were less univocal. A nonsignificant decrease in <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> was only observed after taking paracetamol. <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content> responses to exercise are inconclusive, but seem to worsen after exercise. No adverse effects were seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study evaluates pain scores, <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">CPM<\/jats:styled-content> in response to submaximal exercise in 2 different chronic pain populations and healthy controls. In patients with <jats:styled-content style=\"fixed-case\">RA<\/jats:styled-content>, exercise had positive effects on <jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content>, suggesting normal EIA. In patients with <jats:styled-content style=\"fixed-case\">CFS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>, these positive effects were only observed after paracetamol and results were inconsistent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/papr.12181","type":"journal-article","created":{"date-parts":[[2014,2,17]],"date-time":"2014-02-17T11:57:45Z","timestamp":1392638265000},"page":"98-106","source":"Crossref","is-referenced-by-count":86,"title":["Endogenous Pain Modulation in Response to Exercise in Patients with Rheumatoid Arthritis, Patients with Chronic Fatigue Syndrome and Comorbid Fibromyalgia, and Healthy Controls: A Double\u2010Blind Randomized Controlled Trial"],"prefix":"10.1111","volume":"15","author":[{"given":"Mira","family":"Meeus","sequence":"first","affiliation":[{"name":"Departments of Human Physiology and Rehabilitation Sciences Faculty of Physical Education and Physiotherapy Vrije Universiteit Brussel Brussels 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